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Critical Care
Published in: Critical Care 3/2011

Open Access 01-06-2011 | Research

Haemodynamic goal-directed therapy and postoperative infections: earlier is better. a systematic review and meta-analysis

Authors: Lidia Dalfino, Maria T Giglio, Filomena Puntillo, Massimo Marucci, Nicola Brienza

Published in: Critical Care | Issue 3/2011

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Abstract

Introduction

Infectious complications are the main causes of postoperative morbidity. The early timing of their promoting factors is the rationale for perioperative strategies attempting to reduce them. Our aim was to determine the effects of perioperative haemodynamic goal-directed therapy on postoperative infection rates.

Methods

We performed a systematic review and meta-analysis. MEDLINE, EMBASE, The Cochrane Library and the DARE databases were searched up to March 2011. Randomised, controlled trials of major surgery in adult patients managed with perioperative goal-directed therapy or according to routine haemodynamic practice were included. Primary outcome measure was specific type of infection.

Results

Twenty-six randomised, controlled trials with a combined total of 4,188 participants met our inclusion criteria. Perioperative goal-directed therapy significantly reduced surgical site infections (pooled OR 0.58, 95% CI 0.46 to 0.74; P < 0.0001), pneumonia (pooled OR 0.71, 95% CI 0.55 to 0.92; P = 0.009), and urinary tract infections (pooled OR 0.44, 95% CI 0.22 to 0.84; P = 0.02). A significant benefit was found regarding total infectious episodes (OR 0.40, 95% CI 0.28 to 0.58; P < 0.00001).

Conclusions

Flow-directed haemodynamic therapy designed to optimise oxygen delivery protects surgical patients against postoperative hospital-acquired infections and must be strongly encouraged, particularly in the high-risk surgical population.
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Metadata
Title
Haemodynamic goal-directed therapy and postoperative infections: earlier is better. a systematic review and meta-analysis
Authors
Lidia Dalfino
Maria T Giglio
Filomena Puntillo
Massimo Marucci
Nicola Brienza
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 3/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10284

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