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Critical Care
Published in: Critical Care 3/2011

01-06-2011 | Letter

Measurement of monocyte apoptosis, plasma IL-1β and PR3 activity as an approach to evaluate the immunological status in sepsis

Authors: Hong-Ping Qu, Zhao-Jun Liu, Jia-Lin Liu

Published in: Critical Care | Issue 3/2011

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Excerpt

In a previous issue of Critical Care, Giamarellos-Bourboulis and colleagues published an article in which they drew a conclusion that inhibition of caspase-1 and defective IL-1β production is an important immunological feature in sepsis [1]. Based on the knowledge of previous research, we would like to make some remarks. …
Literature
1.
Giamarellos-Bourboulis EJ, van de Veerdonk FL, Mouktaroudi M, Raftogiannis M, Antonopoulou A, Joosten LA, Pickkers P, Savva A, Georgitsi M, van der Meer JW, Netea MG: Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia. Crit Care 2011, 15: R27. 10.1186/cc9974PubMedCentralCrossRefPubMed
2.
Giamarellos-Bourboulis EJ, Routsi C, Plachouras D, Markaki V, Raftogiannis M, Zervakis D, Koussoulas V, Orfanos S, Kotanidou A, Armaganidis A, Roussos C, Giamarellou H: Early apoptosis of blood monocytes in the septic host: is it a mechanism of protection in the event of septic shock? Crit Care 2006, 10: R76. 10.1186/cc4921PubMedCentralCrossRefPubMed
3.
Fahy RJ, Exline MC, Gavril in MA, Bhatt NY, Besecker BY, Sarkar A, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall M, Wewers MD: Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med 2008, 177: 983-988. 10.1164/rccm.200703-418OCPubMedCentralCrossRefPubMed
4.
van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA: Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol 2011, 32: 110-116. 10.1016/j.it.2011.01.003CrossRefPubMed
Metadata
Title
Measurement of monocyte apoptosis, plasma IL-1β and PR3 activity as an approach to evaluate the immunological status in sepsis
Authors
Hong-Ping Qu
Zhao-Jun Liu
Jia-Lin Liu
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 3/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10248

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