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Critical Care
Published in: Critical Care 3/2011

01-06-2011 | Letter

Soluble CD40 ligand, a mediator of sepsis or of transfusion-related adverse effects?

Authors: Pieter R Tuinman, Nicole P Juffermans

Published in: Critical Care | Issue 3/2011

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Excerpt

Dr Lorente and colleagues [1] report on the interesting association between serum soluble CD40 ligand (sCD40L) levels and mortality in patients with sepsis. Some variables that can influence outcome in sepsis were accounted for in their analysis. However, the amount of transfused blood products, which may influence levels of sCD40L, was not reported. …
Literature
1.
Lorente L, Martín MM, Varo N, Borreguero-León JM, Solé-Violán J, Blanquer J, Labarta L, Díaz C, Jiménez A, Pastor E, Belmonte F, Orbe J, Rodríguez JA, Gómez-Melini E, Ferrer-Agüero JM, Ferreres J, Llimiñana MC, Páramo JA: Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care 2011, 15: R97. 10.1186/cc10104PubMedCentralCrossRefPubMed
2.
Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, Gettings KF, McLaughlin NJ, Silliman CC: Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood 2006, 108: 2455-2462. 10.1182/blood-2006-04-017251PubMedCentralCrossRefPubMed
3.
Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP: The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res 2009, 45: 251-260. 10.1007/s12026-009-8106-9CrossRefPubMed
4.
Marik PE, Corwin HL: Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 2008, 36: 2667-2674. 10.1097/CCM.0b013e3181844677CrossRefPubMed
5.
Juffermans NP, Prins DJ, Vlaar AP, Nieuwland R, Binnekade JM: Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study. Shock 2011, 35: 355-359. 10.1097/SHK.0b013e3182086094CrossRefPubMed
6.
Rahman M, Zhang S, Chew M, Ersson A, Jeppsson B, Thorlacius H: Platelet-derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg 2009, 250: 783-790. 10.1097/SLA.0b013e3181bd95b7CrossRefPubMed
Metadata
Title
Soluble CD40 ligand, a mediator of sepsis or of transfusion-related adverse effects?
Authors
Pieter R Tuinman
Nicole P Juffermans
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 3/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10237

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