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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Research

Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study

Authors: Vincent Minville, Karim Asehnoune, Stephanie Ruiz, Audrey Breden, Bernard Georges, Thierry Seguin, Ivan Tack, Acil Jaafar, Sylvie Saivin, Olivier Fourcade, Kamran Samii, Jean Marie Conil

Published in: Critical Care | Issue 1/2011

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Abstract

Introduction

The aim of this study, performed in an intensive care unit (ICU) population with a normal serum creatinine, was to estimate urinary creatinine clearance (CLCR) in a population of polytrauma patients (PT) through a comparison with a population of non trauma patients (NPT).

Methods

This was a retrospective, observational study in a medical and surgical ICU in a university hospital. A total of 284 patients were consecutively included. Two different groups were studied: PT (n = 144) and NPT (n = 140). Within the second week after admission to the ICU, renal function was assessed using serum creatinine, 24 h urinary CLCR .

Results

Among the 106 patients with a CLCR above 120 mL minute-1 1.73 m-2, 79 were PT and 27 NPT (P < 0.0001). Only 63 patients had a CLCR below 60 mL minute-1 1.73 m-2 with 15 PT and 48 NPT (P < 0.0001). Patients with CLCR greater than 120 mL minute-1. 1.73 m -2 were younger, had a lower SAPS II score and a higher male ratio as compared to those having CLCR lower than 120 mL minute-1. 1.73 m -2. Through a logistic regression analysis, age and trauma were the only factors independently correlated to CLCR.

Conclusions

In ICU patients with normal serum creatinine, CLCR, is higher in PT than in NPT. The measure of CLCR should be proposed as routine for PT patients in order to adjust dose regimen, especially for drugs with renal elimination.
Appendix
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Metadata
Title
Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study
Authors
Vincent Minville
Karim Asehnoune
Stephanie Ruiz
Audrey Breden
Bernard Georges
Thierry Seguin
Ivan Tack
Acil Jaafar
Sylvie Saivin
Olivier Fourcade
Kamran Samii
Jean Marie Conil
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10013

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