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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Research

Hormonal status in protracted critical illness and in-hospital mortality

Authors: Tarek Sharshar, Sylvie Bastuji-Garin, Andrea Polito, Bernard De Jonghe, Robert D Stevens, Virginie Maxime, Pablo Rodriguez, Charles Cerf, Hervé Outin, Philippe Touraine, Kathleen Laborde, the Groupe de Réflexion et d'Etude des Neuromyopathies En Réanimation

Published in: Critical Care | Issue 1/2011

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Abstract

Introduction

The aim of this study was to determine the relationship between hormonal status and mortality in patients with protracted critical illness.

Methods

We conducted a prospective observational study in four medical and surgical intensive care units (ICUs). ICU patients who regained consciousness after 7 days of mechanical ventilation were included. Plasma levels of insulin-like growth factor 1 (IGF-1), prolactin, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS) and cortisol were measured on the first day patients were awake and cooperative (day 1). Mean blood glucose from admission to day 1 was calculated.

Results

We studied 102 patients: 65 men and 37 women (29 of the women were postmenopausal). Twenty-four patients (24%) died in the hospital. The IGF-1 levels were higher and the cortisol levels were lower in survivors. Mean blood glucose was lower in women who survived, and DHEA and DHEAS were higher in men who survived.

Conclusions

These results suggest that, on the basis of sex, some endocrine or metabolic markers measured in the postacute phase of critical illness might have a prognostic value.
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Metadata
Title
Hormonal status in protracted critical illness and in-hospital mortality
Authors
Tarek Sharshar
Sylvie Bastuji-Garin
Andrea Polito
Bernard De Jonghe
Robert D Stevens
Virginie Maxime
Pablo Rodriguez
Charles Cerf
Hervé Outin
Philippe Touraine
Kathleen Laborde
the Groupe de Réflexion et d'Etude des Neuromyopathies En Réanimation
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10010

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