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Breast Cancer Research
Published in: Breast Cancer Research 6/2000

01-12-2000 | Review

Molecular biology of breast cancer metastasis Inflammatory breast cancer: clinical syndrome and molecular determinants

Authors: Celina G Kleer, Kenneth L van Golen, Sofia D Merajver

Published in: Breast Cancer Research | Issue 6/2000

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Abstract

Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and pathologically distinct form of LABC that is particularly fast growing, invasive, and angiogenic. Nearly all women have lymph node involvement at the time of diagnosis, and approximately 36% have gross distant metastases. Despite recent advances in multimodality treatments, the prognosis of patients with IBC is poor, with a median disease-free survival of less than 2.5 years. Recent work on the genetic determinants that underlie the IBC phenotype has led to the identification of genes that are involved in the development and progression of this disease. This work has been aided by the establishment of primary human cell lines and animal models. These advances suggest novel targets for future interventions in the diagnosis and treatment of IBC.
Literature
1.
Lee BJ, Tannenbaum NE: Inflammatory carcinoma of the breast: a report of twenty-eight cases from the breast clinic of Memorial Hospital. Surg Gynecol Obstet. 1924, 39: 580-595.
2.
Haagensen CD: . Diseases of the Breast. Philadelphia: WB Saunders,. 1986
3.
Piera JM, Alonso MC, Ojeda MB: Locally advanced breast cancer with inflammatory component: a clinical entity with a poor prognosis. Rad Oncol. 1986, 7: 199-204.CrossRef
4.
Stocks LH, Patternson FM: Inflammatory carcinoma of the breast. Surg Gynecol Obstet. 1976, 143: 885-889.PubMed
5.
Rosen PP: . Rosen's Breast Pathology. Philadelphia: Lippincott-Raven,. 1996
6.
Robbins GF, Shah J, Rosen P, Chu F, Taylor J: Inflammatory carcinoma of the breast. Surg Clin North Am. 1974, 54: 801-810.CrossRefPubMed
7.
Haagensen CD, Stout AP: Carcinoma of the breast II - criteria of operability. Ann Surg. 1942, 118: 859-870.CrossRef
8.
Baclesse F: Roentgen therapy alone as the method of treatment of cancer of the breast. AJR Am J Roentgenol. 1949, 62: 311-319.
9.
Bruckman JE, Harris JR, Levene MB, Chaffey JT, Hellman S: Results of treating stage III carcinoma of the breast by primary radiation therapy. Cancer. 1979, 43: 985-993.CrossRefPubMed
10.
Zucali R, Uslenghi C, Kenda R, Bonadonna G: Natural history of survival of inoperable breast cancer treated with radiotherapy and radiotherapy followed by radical mastectomy. Cancer. 1976, 37: 1422-1431.CrossRefPubMed
11.
DeLena M, Zucali R, Viganotti G: Combined chemotherapy-radiotherapy approach in locally advanced (T3b-T4) breast cancer. Cancer Chemother Pharmacol. 1978, 1: 53-59.CrossRef
12.
Hortobagyi GN, Blumenschein GR, Spanos W, Montague ED, Buzdar AU, Yap HY, Schell F: Multimodal treatment of locoregionally advanced breast cancer. Cancer. 1983, 51: 763-768.CrossRefPubMed
13.
Rouesse S, Sarrazin D, Mouriesse H, Le Chevalier T, Arriagada R, Spielmann M, Papacharalambous A, May-Levin F: Primary chemotherapy in the treatment of inflammatory breast carcinoma: a study of 230 cases from the Institut Gustave-Roussy. J Clin Oncol. 1986, 4: 1765-1771.PubMed
14.
Swain SM, Sorace RA, Bagley CS, Danforth DN, Bader J, Wesley MN, Steinberg SM, Lippman ME: Neoadjuvant chemotherapy in the combined modality approach of locally advanced nonmetastatic breast cancer. Cancer Res. 1987, 47: 3889-3894.PubMed
15.
Merajver SD, Weber BL, Cody R, Zhang D, Strawderman M, Calzone KA, LeClaire V, Levin A, Irani J, Halvie M, August D, Wicha M, Lichter A, Pierce LJ: Breast conservation and prolonged chemotherapy for locally advanced breast cancer: the University of Michigan experience. J Clin Oncol. 1997, 15: 2873-2881.PubMed
16.
Abner AL, Recht A, Eberlein T, Come S, Shulman L, Hayes D, Connolly JL, Schnitt SJ, Silver B, Harris JR: Prognosis following salvage mastectomy for recurrence in the breast after conservative surgery and radiation therapy for early-stage breast cancer. J Clin Oncol . 1993, 11: 44-48.PubMed
17.
Hortobagyi GN, Ames FC, Buzdar AU, Kau SW, McNeese MD, Paulus D, Hug V, Holmes FA, Romsdahl MM, Fraschini G, McBride CM, Martin RG, Montague E: Management of stage III primary breast cancer with primary chemotherapy, surgery, and radiation therapy. Cancer. 1988, 62: 2507-2516.CrossRefPubMed
18.
Jaiyesimi I, Buzdar A, Hortobagyi G: Inflammatory breast cancer: a review. J Clin Oncol. 1992, 10: 1014-1024.PubMed
19.
Kaufman M: Review of known prognostic variables. Results Probl Cell Differ. 2000, 140: 77-87.
20.
Koh E, Buzdar A, Ames FC, Singletary SE, McNeese MD, Frye D, Holmes FA, Fraschini G, Hug V, Theriault RL: Inflammatory carcinoma of the breast: results of a combined-modality approach -M.D. Anderson Cancer Center Experience. Cancer Chemother Pharmacol. 1990, 27: 94-100.CrossRefPubMed
21.
Hahnel R, Twaddle E: Estrogen receptors in human breast cancer.1. Methodology and characterization of receptors. Steroids . 1971, 18: 653-680. 10.1016/0039-128X(71)90029-8.CrossRefPubMed
22.
Robertson JFR, Ellis IO, Pearson D, Elston CW, Nicholson RI, Blamey RW: Biological factors of prognostic significance in locally advanced breast cancer. Breast Cancer Res Treat. 1994, 29: 259-264.CrossRefPubMed
23.
Paradiso A, Tommasi S, Brandi M, Marzullo F, Simone G, Lorusso V, Mangia A, deLena M: Cell kinetics and hormonal receptor status in inflammatory breast carcinoma. Cancer. 1989, 64: 1922-1927.CrossRefPubMed
24.
Guerin M, Sheng ZM, Andrieu N, Riou G: Strong association between c-myb and oestrogen-receptor expression in human breast cancer. Oncogene. 1990, 5: 131-135.PubMed
25.
Blondal JA, Benchimol S: The role of p53 in tumor progression. Semin Cancer Biol. 1994, 5: 177-186.PubMed
26.
Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FS, Weston A, Modali R, Harris CC, Vogelstein B: Mutations in the p53 gene occur in diverse human tumour types. Nature. 1989, 342: 705-708. 10.1038/342705a0.CrossRefPubMed
27.
Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M: Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature. 1991, 352: 345-347. 10.1038/352345a0.CrossRefPubMed
28.
Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, van Tuinen P, Ledbetter DH, Baker D, Nakamura Y: Chromosome 17 deletions and p53 gene muations in colorectal carcinoma. Science . 1989, 244: 217-221.CrossRefPubMed
29.
Moll UM, Riou G, Levine AJ: Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA. 1992, 89: 7262-7266.CrossRefPubMedPubMedCentral
30.
Davidoff A, Humphrey P, Iglehart JD, Marks JR: Genetic basis for p53 overexpression in human breast cancer. Proc Nat Acad Sci USA . 1991, 88: 5006-5010.CrossRefPubMedPubMedCentral
31.
Moll U, Riou G, Levin A: Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA. 1992, 89: 7262-7266.CrossRefPubMedPubMedCentral
32.
Riou G, Le M, Travagli J-P, Levin A, Moll U: Poor prognosis of p53 gene mutation and nuclear overexpression of p53 protein in inflammatory breast carcinoma. J Natl Cancer Inst. 1993, 85: 1765-1767.CrossRefPubMed
33.
Faille A, DeCremoux P, Extra JM, Linares G, Espie M, Bourstyn E, DeRocquancourt A, Giacchetti S, Marty M, Calvo F: p53 mutations and overexpression in locally advanced breast cancers. Br J Cancer. 1994, 69: 1145-1150.CrossRefPubMedPubMedCentral
34.
van Golen KL, Davies S, Wu ZF, Wang Y, Bucana CD, Root H, Chandrasekharappa S, Strawderman M, Ethier SP, Merajver SD: A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res. 1999, 5: 2511-2519.PubMed
35.
Hwa V: The IGFBP superfamily. Growth Hormone IGF Res . 1999, 9: 299-307. 10.1054/ghir.1999.0123.CrossRef
36.
Ridley A: The GTP-binding Protein Rho. Int J Biochem Cell Biol. 29: 1225-1229.
37.
Prendergast C, Khosravi-Far R, Solski P, Kurzawa H, Lebowitz P, Der C: Critical role of Rho in cell transformation by oncogenic Ras. Oncogene. 1995, 10: 2289-2296.PubMed
38.
Hall A: Rho GTPases and the actin cytoskeleton. Science . 1998, 279: 509-514. 10.1126/science.279.5350.509.CrossRefPubMed
39.
Nobes CD, Hall A: Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol. 1999, 144: 1235-1244. 10.1083/jcb.144.6.1235.CrossRefPubMedPubMedCentral
40.
Suwa H, Ohshio G, Imamura T, Watanabe G, Arii S, Imamura M, Narumiya S, Hiai H, Fukumoto M: Overexpression of the RhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer . 1998, 77: 147-152.CrossRefPubMedPubMedCentral
41.
Clemons D: Role of insulin-like growth factor binding proteins in controling IGF actions. Mol Cell Endocrinol. 1998, 140: 19-24. 10.1016/S0303-7207(98)00024-0.CrossRef
42.
Oh Y: IGF-independent regulation of breast cancer growth by IGF binding proteins. Breast Cancer Res Treat. 1998, 47: 283-293. 10.1023/A:1005911319432.CrossRefPubMed
43.
Burger A, Zhang X, Li H, Ostrowski J, Beatty B, Venanzoni M, Papas T, Seth A: Down-regulation of T1A12/mac25, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas. Oncogene. 1998, 16: 2459-2467. 10.1038/sj/onc/1201772.CrossRefPubMed
44.
Sprenger CC, Damon SE, Hwa V, Rosenfeld R, Plymate SR: Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor supressor for prostate cancer. Cancer Res. 1999, 59: 2370-2375.PubMed
45.
Achen M, Jeltsch M, Kukk E, Makinen T, Vitali A, Wilks A, Alitalo K, Stacker S: Vascular enothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flt 1) and VEGF receptor 3 (Flt 4). Proc Natl Acad Sci USA. 1998, 95: 548-553. 10.1073/pnas.95.2.548.CrossRefPubMedPubMedCentral
46.
Kurebayashi J, Ostuski T, Kunisue H, Mikami Y, Tanaka K, Yamamoto S, Sonoo H: Expression of vascular endothelial growth factor (VEGF) family members in breast cancer. Jpn J Cancer Res. 1999, 90: 977-981.CrossRefPubMed
47.
Forozan F, Veldman R, Ammerman CA, Parsa NZ, Kallioniemi A, Kallioniemi OP, Ethier SP: Molecular cytogenetic analysis of 11 new breast cancer cell lines. Br J Cancer. 1999, 81: 1328-1334. 10.1038/sj.bjc.6695007.CrossRefPubMedPubMedCentral
48.
Alpaugh ML, Tomlinson JS, Shao Z-M, Barsky SH: A novel human xenograft model of inflammatory breast cancer. Cancer Res. 1999, 59: 5079-5084.PubMed
49.
Ethier SP: Human breast cancer cell lines as models of growth regulation and disease progression. J Mammary Gland Biol Neoplasia . 1996, 1: 111-121.CrossRefPubMed
Metadata
Title
Molecular biology of breast cancer metastasis Inflammatory breast cancer: clinical syndrome and molecular determinants
Authors
Celina G Kleer
Kenneth L van Golen
Sofia D Merajver
Publication date
01-12-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr89

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