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Breast Cancer Research
Published in: Breast Cancer Research 6/2000

01-12-2000 | Review

Molecular biology of breast cancer metastasis Genetic regulation of human breast carcinoma metastasis

Authors: Danny R Welch, Patricia S Steeg, Carrie W Rinker-Schaeffer

Published in: Breast Cancer Research | Issue 6/2000

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Abstract

The present is an overview of recent data that describes the genetic underpinnings of the suppression of cancer metastasis. Despite the explosion of new information about the genetics of cancer, only six human genes have thus far been shown to suppress metastasis functionally. Not all have been shown to be functional in breast carcinoma. Several additional genes inhibit various steps of the metastatic cascade, but do not necessarily block metastasis when tested using in vivo assays. The implications of this are discussed. Two recently discovered metastasis suppressor genes block proliferation of tumor cells at a secondary site, offering a new target for therapeutic intervention.
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Metadata
Title
Molecular biology of breast cancer metastasis Genetic regulation of human breast carcinoma metastasis
Authors
Danny R Welch
Patricia S Steeg
Carrie W Rinker-Schaeffer
Publication date
01-12-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr87

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