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Breast Cancer Research
Published in: Breast Cancer Research 5/2003

01-10-2003 | Review

Oestrogen exposure and breast cancer risk

Authors: Ruth C Travis, Timothy J Key

Published in: Breast Cancer Research | Issue 5/2003

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Abstract

Epidemiological and experimental evidence implicates oestrogens in the aetiology of breast cancer. Most established risk factors for breast cancer in humans probably act through hormone-related pathways, and increased concentrations of circulating oestrogens have been found to be strongly associated with increased risk for breast cancer in postmenopausal women. This article explores the evidence for the hypothesis that oestrogen exposure is a major determinant of risk for breast cancer. We review recent data on oestrogens and breast cancer risk, consider oestrogen-related risk factors and examine possible mechanisms that might account for the effects of oestrogen. Finally, we discuss how these advances might influence strategies for reducing the incidence of breast cancer.
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Metadata
Title
Oestrogen exposure and breast cancer risk
Authors
Ruth C Travis
Timothy J Key
Publication date
01-10-2003
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2003
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr628

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Articles selected from Faculty of 1000 in September 2003

Review

The diagnosis and management of pre-invasive breast disease: Pathological diagnosis – problems with existing classifications

Research article

First-cycle absolute neutrophil count can be used to improve chemotherapy-dose delivery and reduce the risk of febrile neutropenia in patients receiving adjuvant therapy: a validation study

Research article

BRCA2mutation carriers, reproductive factors and breast cancer risk

Commentary

Breast cancer in Marin County
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
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