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Breast Cancer Research
Published in: Breast Cancer Research 5/2002

01-10-2002 | Commentary

IkB kinase alpha: a link in the chain of the mammary cycle

Author: Richard Clarkson

Published in: Breast Cancer Research | Issue 5/2002

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Abstract

The transcription factor NF-κB exhibits altered activity in some breast cancers but the relevance of this association has not been established. Cao et al.'s elegant study recently published in Cell reveals a NF-κB-dependent signalling pathway responsible for epithelial proliferation in the mouse mammary gland. Could this mechanism, rather than prevention of apoptosis, be responsible for the reported association between NF-κB and breast cancer? Could the specificity of NF-κB modulators of the IkB kinase complex determine the fate of epithelial cells at different stages of mammary development?
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Metadata
Title
IkB kinase alpha: a link in the chain of the mammary cycle
Author
Richard Clarkson
Publication date
01-10-2002
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2002
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr446

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