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Breast Cancer Research
Published in: Breast Cancer Research 3/2002

01-06-2002 | Commentary

The contribution of inherited genotype to breast cancer

Author: Timothy R Rebbeck, PhD

Published in: Breast Cancer Research | Issue 3/2002

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Abstract

The etiology of breast cancer is complex, and is likely to involve the actions of genes at multiple levels along the multistage carcinogenesis process. These inherited genotypes include those that affect the propensity to be exposed to breast carcinogens, and those associated with breast tumorigenesis directly. In addition, inherited genotypes may influence response to breast cancer chemoprevention and treatment. Studies relating inherited genotypes with breast cancer incidence and mortality should consider a broader spectrum of genes and their potential roles in multistage carcinogenesis than have been typically evaluated to date. Understanding the role of inherited genotype at different stages of carcinogenesis could improve our understanding of cancer biology, may identify specific exposures or events that correlate with carcinogenesis, or target relevant biochemical pathways for the development of preventive or therapeutic interventions.
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Metadata
Title
The contribution of inherited genotype to breast cancer
Author
Timothy R Rebbeck, PhD
Publication date
01-06-2002
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2002
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr430

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