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Breast Cancer Research
Published in: Breast Cancer Research 3/2014

Open Access 01-06-2014 | Viewpoint

CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer

Authors: Olafur A Stefansson, Manel Esteller

Published in: Breast Cancer Research | Issue 3/2014

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Abstract

In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues. This modification leads to the relocalization of BAF155-containing SWI/SNF complexes to regions containing genes involved in the Myc oncogenic pathway. The results presented are evidence that these interactions constitute a mechanism by which the BAF155 chromatin remodeling factor contributes to cancer.
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Metadata
Title
CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer
Authors
Olafur A Stefansson
Manel Esteller
Publication date
01-06-2014
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2014
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3657

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