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Breast Cancer Research
Published in: Breast Cancer Research 5/2012

01-10-2012 | Viewpoint

Slugging their way to immortality: driving mammary epithelial cells into a stem cell-like state

Authors: Kelly Soady, Matthew J Smalley

Published in: Breast Cancer Research | Issue 5/2012

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Abstract

Delineating the molecular factors that define and maintain the mammary stem cell state is vital for understanding normal development and tumourigenesis. A recent study by Guo and colleagues identifies two master transcriptional regulators of mammary stem cells, Slug and Sox9, ectopic expression of which confers stem cell attributes on differentiated mammary epithelial cells. Slug and Sox9 expression was also shown to determine in vivo metastatic potential of human breast cancer cell lines. Understanding these factors in the context of normal lineage differentiation is an important step toward elucidating the mammary epithelial cell hierarchy and the origins of cancer stem cells.
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Metadata
Title
Slugging their way to immortality: driving mammary epithelial cells into a stem cell-like state
Authors
Kelly Soady
Matthew J Smalley
Publication date
01-10-2012
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2012
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3188

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