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01-04-2012 | Viewpoint

BRCA1 as tumor suppressor: lord without its RING?

Authors: Andrew EH Elia, Stephen J Elledge

Published in: Breast Cancer Research | Issue 2/2012

Abstract

BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long suspected that BRCA1's ubiquitin ligase is important for its tumor suppression and DNA repair activities. Using genetically engineered mouse models, two recent studies shed light on this age-old hypothesis.

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Title: BRCA1 as tumor suppressor: lord without its RING?
Authors: Andrew EH Elia
Stephen J Elledge
Publication date: 01-04-2012
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 2/2012
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr3118

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