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Breast Cancer Research
Published in: Breast Cancer Research 6/2011

01-12-2011 | Review

The microenvironment in breast cancer progression: biology and implications for treatment

Authors: Andrew E Place, Sung Jin Huh, Kornelia Polyak

Published in: Breast Cancer Research | Issue 6/2011

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Abstract

Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized as a critical participant in tumor progression and therapeutic responses. Recent data demonstrate significant gene expression and epigenetic alterations in cells composing the microenvironment during disease progression, which can be explored as biomarkers and targets for therapy. Indeed, gene expression signatures derived from tumor stroma have been linked to clinical outcomes. There is increasing interest in translating our current understanding of the tumor microenvironment to the development of novel therapies.
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Metadata
Title
The microenvironment in breast cancer progression: biology and implications for treatment
Authors
Andrew E Place
Sung Jin Huh
Kornelia Polyak
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2912

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