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Breast Cancer Research
Published in: Breast Cancer Research 3/2011

01-06-2011 | Viewpoint

Heating cancer stem cells to reduce tumor relapse

Authors: Pier Giuseppe Pelicci, Paola Dalton, Roberto Orecchia

Published in: Breast Cancer Research | Issue 3/2011

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Abstract

Tumour relapse is believed to be caused by rare cancer-cells with stem-cell properties (cancer stem cells) that are intrinsically resistant to available treatments. The identification of novel strategies to increase their sensitivity has major clinical implications. Latest clinical trials have shown a positive antitumoral effect of hyperthermia in combination with chemotherapy or radiotherapy. In a recent paper, the combination of increased temperature at the tumour site, generated by laser treatment of intravenously-injected gold nanoshells, and ionizing radiations enhances radiosensitivity of cancer stem cells and tumor response. At the root of the success of hyperthermia in enhancing radio-sensitization of cancer stem cells is the inhibition of their capacity to repair DNA damage, affecting the survival rate of these cells.
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Metadata
Title
Heating cancer stem cells to reduce tumor relapse
Authors
Pier Giuseppe Pelicci
Paola Dalton
Roberto Orecchia
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2847

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