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Published in: Breast Cancer Research 2/2011

01-04-2011 | Review

Stress and breast cancer: from epidemiology to molecular biology

Authors: Lilia Antonova, Kristan Aronson, Christopher R Mueller

Published in: Breast Cancer Research | Issue 2/2011

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Abstract

Stress exposure has been proposed to contribute to the etiology of breast cancer. However, the validity of this assertion and the possible mechanisms involved are not well established. Epidemiologic studies differ in their assessment of the relative contribution of stress to breast cancer risk, while physiological studies propose a clear connection but lack the knowledge of intracellular pathways involved. The present review aims to consolidate the findings from different fields of research (including epidemiology, physiology, and molecular biology) in order to present a comprehensive picture of what we know to date about the role of stress in breast cancer development.
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Literature
1.
go back to reference Madigan M, Ziegler R, Benichou J, Byrne C, Hoover R: Proportion of breast cancer cases in the United States explained by well-established risk factors. J Natl Cancer Inst. 1995, 87: 1681-1685. 10.1093/jnci/87.22.1681.PubMedCrossRef Madigan M, Ziegler R, Benichou J, Byrne C, Hoover R: Proportion of breast cancer cases in the United States explained by well-established risk factors. J Natl Cancer Inst. 1995, 87: 1681-1685. 10.1093/jnci/87.22.1681.PubMedCrossRef
2.
go back to reference Tonin P: Genes implicated in hereditary breast cancer syndromes. Semin Surg Oncol. 2000, 18: 281-286. 10.1002/(SICI)1098-2388(200006)18:4<281::AID-SSU2>3.0.CO;2-Q.PubMedCrossRef Tonin P: Genes implicated in hereditary breast cancer syndromes. Semin Surg Oncol. 2000, 18: 281-286. 10.1002/(SICI)1098-2388(200006)18:4<281::AID-SSU2>3.0.CO;2-Q.PubMedCrossRef
3.
go back to reference Hankiston S, Colditz G, Willett W: Towards an integrated model for breast cancer etiology. The lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res. 2004, 6: 213-218. 10.1186/bcr921.CrossRef Hankiston S, Colditz G, Willett W: Towards an integrated model for breast cancer etiology. The lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res. 2004, 6: 213-218. 10.1186/bcr921.CrossRef
4.
go back to reference Gerber B, Muller H, Reimer T, Krause A, Friese K: Nutrition and lifestyle factors on the risk of developing breast cancer. Breast Cancer Res Treat. 2003, 79: 265-276. 10.1023/A:1023959818513.PubMedCrossRef Gerber B, Muller H, Reimer T, Krause A, Friese K: Nutrition and lifestyle factors on the risk of developing breast cancer. Breast Cancer Res Treat. 2003, 79: 265-276. 10.1023/A:1023959818513.PubMedCrossRef
5.
go back to reference Bleiker E, van der Ploeg H: Psychosocial factors in the etiology of breast cancer: review of a popular link. Patient Educ Couns. 1999, 37: 201-214. 10.1016/S0738-3991(99)00027-0.PubMedCrossRef Bleiker E, van der Ploeg H: Psychosocial factors in the etiology of breast cancer: review of a popular link. Patient Educ Couns. 1999, 37: 201-214. 10.1016/S0738-3991(99)00027-0.PubMedCrossRef
6.
go back to reference Schwarz R, Geyer S: Social and psychological differences between cancer and noncancer patients: cause or consequence of the disease?. Psychother Psychosom. 1984, 41: 195-199. 10.1159/000287809.PubMedCrossRef Schwarz R, Geyer S: Social and psychological differences between cancer and noncancer patients: cause or consequence of the disease?. Psychother Psychosom. 1984, 41: 195-199. 10.1159/000287809.PubMedCrossRef
7.
go back to reference Petticrew M, Fraser J, Regan M: Adverse life-events and risk of breast cancer: a meta-analysis. Br J Health Psychol. 1999, 4: 1-17. 10.1348/135910799168434.CrossRef Petticrew M, Fraser J, Regan M: Adverse life-events and risk of breast cancer: a meta-analysis. Br J Health Psychol. 1999, 4: 1-17. 10.1348/135910799168434.CrossRef
8.
go back to reference Duijts S, Zeegers M, Vd Borne B: The association between stressful life events and breast cancer risk: a meta-analysis. Int J Cancer. 2003, 107: 1023-1029. 10.1002/ijc.11504.PubMedCrossRef Duijts S, Zeegers M, Vd Borne B: The association between stressful life events and breast cancer risk: a meta-analysis. Int J Cancer. 2003, 107: 1023-1029. 10.1002/ijc.11504.PubMedCrossRef
9.
go back to reference Nielsen N, Gronbaek M: Stress and breast cancer: a systemic update on the current knowledge. Nat Clin Pract Oncol. 2006, 3: 612-620. 10.1038/ncponc0652.PubMedCrossRef Nielsen N, Gronbaek M: Stress and breast cancer: a systemic update on the current knowledge. Nat Clin Pract Oncol. 2006, 3: 612-620. 10.1038/ncponc0652.PubMedCrossRef
10.
go back to reference Michael Y, Carlson N, Chlebowski R, Aickin M, Weihs K, Ockene J, Bowen D, Ritenbaugh C: Influence of stressors on breast cancer incidence in the Women's Health Initiative. Health Psychol. 2009, 28: 137-146. 10.1037/a0012982.PubMedPubMedCentralCrossRef Michael Y, Carlson N, Chlebowski R, Aickin M, Weihs K, Ockene J, Bowen D, Ritenbaugh C: Influence of stressors on breast cancer incidence in the Women's Health Initiative. Health Psychol. 2009, 28: 137-146. 10.1037/a0012982.PubMedPubMedCentralCrossRef
11.
go back to reference Helgesson O, Cabrera C, Lapidus L, Bengtsson C, Lissner L: Self-reported stress levels predict subsequent breast cancer in a cohort of Swedish women. Eur J Cancer Prev. 2003, 12: 377-381. 10.1097/00008469-200310000-00006.PubMedCrossRef Helgesson O, Cabrera C, Lapidus L, Bengtsson C, Lissner L: Self-reported stress levels predict subsequent breast cancer in a cohort of Swedish women. Eur J Cancer Prev. 2003, 12: 377-381. 10.1097/00008469-200310000-00006.PubMedCrossRef
12.
go back to reference Matthews K, Gallo L, Taylor S: Are psychosocial factors mediators of socioeconomic status and health connections?. Ann NY Acad Sci. 2010, 1186: 146-173. 10.1111/j.1749-6632.2009.05332.x.PubMedCrossRef Matthews K, Gallo L, Taylor S: Are psychosocial factors mediators of socioeconomic status and health connections?. Ann NY Acad Sci. 2010, 1186: 146-173. 10.1111/j.1749-6632.2009.05332.x.PubMedCrossRef
13.
go back to reference Chida Y, Hamer M: Chronic psychosocial factors and actute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations. Psychol Bull. 2008, 134: 829-885. 10.1037/a0013342.PubMedCrossRef Chida Y, Hamer M: Chronic psychosocial factors and actute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations. Psychol Bull. 2008, 134: 829-885. 10.1037/a0013342.PubMedCrossRef
14.
go back to reference Chrousos G: Stress and disorders of the stress system. Nat Rev Endocrinol. 2009, 5: 374-381. 10.1038/nrendo.2009.106.PubMedCrossRef Chrousos G: Stress and disorders of the stress system. Nat Rev Endocrinol. 2009, 5: 374-381. 10.1038/nrendo.2009.106.PubMedCrossRef
15.
go back to reference Kuper H, Yang L, Theorell T, Weiderpass E: Job strain and risk of breast cancer. Epidemiology. 2007, 18: 764-768. 10.1097/EDE.0b013e318142c534.PubMedCrossRef Kuper H, Yang L, Theorell T, Weiderpass E: Job strain and risk of breast cancer. Epidemiology. 2007, 18: 764-768. 10.1097/EDE.0b013e318142c534.PubMedCrossRef
16.
go back to reference Nielsen N, Stahlberg C, Strandberg-Larsen K, Kristensen T, Zhang Z, Hundrup Y, Gronbaek M: Are work-related stressors associated with diagnosis of more advanced stages of incident breast cancers?. Cancer Causes Control. 2008, 19: 297-303. 10.1007/s10552-007-9092-7.PubMedCrossRef Nielsen N, Stahlberg C, Strandberg-Larsen K, Kristensen T, Zhang Z, Hundrup Y, Gronbaek M: Are work-related stressors associated with diagnosis of more advanced stages of incident breast cancers?. Cancer Causes Control. 2008, 19: 297-303. 10.1007/s10552-007-9092-7.PubMedCrossRef
17.
go back to reference Schernhammer E, Hankinson S, Rosner B, Kroenke C, Willett W, Colditz G, Kawachi I: Job stress and breast cancer risk: the Nurses' Health Study. Am J Epidemiol. 2004, 160: 1079-1086. 10.1093/aje/kwh327.PubMedCrossRef Schernhammer E, Hankinson S, Rosner B, Kroenke C, Willett W, Colditz G, Kawachi I: Job stress and breast cancer risk: the Nurses' Health Study. Am J Epidemiol. 2004, 160: 1079-1086. 10.1093/aje/kwh327.PubMedCrossRef
18.
go back to reference Kroenke C, Hankinson S, Schernhammer E, Colditz G, Kawachi I, Holmes M: Caregiving stress, endogenous sex steroid hormone levels, and breast cancer incidence. Am J Epidemiol. 2004, 159: 1019-1027. 10.1093/aje/kwh148.PubMedCrossRef Kroenke C, Hankinson S, Schernhammer E, Colditz G, Kawachi I, Holmes M: Caregiving stress, endogenous sex steroid hormone levels, and breast cancer incidence. Am J Epidemiol. 2004, 159: 1019-1027. 10.1093/aje/kwh148.PubMedCrossRef
19.
go back to reference Nielsen NR, Zhang ZF, Kristensen TS, Netterstrom B, Schnohr P, Gronbaek M: Self reported stress and risk of breast cancer: prospective cohort study. BMJ. 2005, 331: 548-10.1136/bmj.38547.638183.06.PubMedPubMedCentralCrossRef Nielsen NR, Zhang ZF, Kristensen TS, Netterstrom B, Schnohr P, Gronbaek M: Self reported stress and risk of breast cancer: prospective cohort study. BMJ. 2005, 331: 548-10.1136/bmj.38547.638183.06.PubMedPubMedCentralCrossRef
20.
go back to reference Surtees P, Wainwright N, Luben R, Khaw K, Bingham S: No evidence that social stress is associated with breast cancer incidence. Breast Cancer Res Treat. 2010, 120: 169-174. 10.1007/s10549-009-0454-6.PubMedCrossRef Surtees P, Wainwright N, Luben R, Khaw K, Bingham S: No evidence that social stress is associated with breast cancer incidence. Breast Cancer Res Treat. 2010, 120: 169-174. 10.1007/s10549-009-0454-6.PubMedCrossRef
21.
go back to reference Metcalfe C, Davey Smith G, Macleod J, Hart C: The role of self-reported stress in the development of breast cancer and prostate cancer: a prospective cohort study of employed males and females with 30 years of follow-up. Eur J Cancer. 2007, 43: 1060-1065. 10.1016/j.ejca.2007.01.027.PubMedCrossRef Metcalfe C, Davey Smith G, Macleod J, Hart C: The role of self-reported stress in the development of breast cancer and prostate cancer: a prospective cohort study of employed males and females with 30 years of follow-up. Eur J Cancer. 2007, 43: 1060-1065. 10.1016/j.ejca.2007.01.027.PubMedCrossRef
22.
go back to reference Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003, 157: 415-423. 10.1093/aje/kwg002.PubMedCrossRef Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003, 157: 415-423. 10.1093/aje/kwg002.PubMedCrossRef
23.
go back to reference Lambe M, Cerrato R, Askling J, Hsieh C: Maternal breast cancer risk after death of a child. Int J Cancer. 2004, 110: 763-766. 10.1002/ijc.20181.PubMedCrossRef Lambe M, Cerrato R, Askling J, Hsieh C: Maternal breast cancer risk after death of a child. Int J Cancer. 2004, 110: 763-766. 10.1002/ijc.20181.PubMedCrossRef
24.
go back to reference Ollonen P, Lehtonen J, Eskelinen M: Stressful and adverse life experiences in patients with breast symptoms; a prospective case-control study in Kuopio, Finland. Anticancer Res. 2005, 25: 531-536.PubMed Ollonen P, Lehtonen J, Eskelinen M: Stressful and adverse life experiences in patients with breast symptoms; a prospective case-control study in Kuopio, Finland. Anticancer Res. 2005, 25: 531-536.PubMed
25.
go back to reference Land C, Tokunaga M, Koyama K, Soda M, Preston D, Nishimori I, Tokuoka S: Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res. 2003, 160: 707-717. 10.1667/RR3082.PubMedCrossRef Land C, Tokunaga M, Koyama K, Soda M, Preston D, Nishimori I, Tokuoka S: Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res. 2003, 160: 707-717. 10.1667/RR3082.PubMedCrossRef
26.
go back to reference Tokunaga M, Norman JJ, Asano M, Tokuoka S, Ezaki H, Nishimori I, Tsuji Y: Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74. J Natl Cancer Inst. 1979, 62: 1347-1359.PubMed Tokunaga M, Norman JJ, Asano M, Tokuoka S, Ezaki H, Nishimori I, Tsuji Y: Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74. J Natl Cancer Inst. 1979, 62: 1347-1359.PubMed
27.
go back to reference Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003, 157: 415-423. 10.1093/aje/kwg002.PubMedCrossRef Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003, 157: 415-423. 10.1093/aje/kwg002.PubMedCrossRef
28.
go back to reference Eskelinen M, Ollonen P: Life stress due to losses and deficit in childhood and adolescence as breast cancer risk factor: a prospective case-control study in Kuopio, Finland. Anticancer Res. 2010, 30: 4303-4308.PubMed Eskelinen M, Ollonen P: Life stress due to losses and deficit in childhood and adolescence as breast cancer risk factor: a prospective case-control study in Kuopio, Finland. Anticancer Res. 2010, 30: 4303-4308.PubMed
29.
go back to reference Jacobs J, Bovasso G: Early and chronic stress and their relation to breast cancer. Psychol Med. 2000, 30: 669-678. 10.1017/S0033291799002020.PubMedCrossRef Jacobs J, Bovasso G: Early and chronic stress and their relation to breast cancer. Psychol Med. 2000, 30: 669-678. 10.1017/S0033291799002020.PubMedCrossRef
30.
go back to reference Keinan-Boker L, Vin-Raviv N, Liphshitz I, Linn S, Barchana M: Cancer incidence in Israeli Jewish survivors of World War II. J Natl Cancer Inst. 2009, 101: 1489-1500. 10.1093/jnci/djp327.PubMedCrossRef Keinan-Boker L, Vin-Raviv N, Liphshitz I, Linn S, Barchana M: Cancer incidence in Israeli Jewish survivors of World War II. J Natl Cancer Inst. 2009, 101: 1489-1500. 10.1093/jnci/djp327.PubMedCrossRef
31.
go back to reference Koupil I, Plavinskaja S, Parfenova N, Shestov D, Danziger P, Vågerö D: Cancer mortality in women and men who survived the siege of Leningrad (1941-1944). Int J Cancer. 2009, 124: 1416-1421. 10.1002/ijc.24093.PubMedCrossRef Koupil I, Plavinskaja S, Parfenova N, Shestov D, Danziger P, Vågerö D: Cancer mortality in women and men who survived the siege of Leningrad (1941-1944). Int J Cancer. 2009, 124: 1416-1421. 10.1002/ijc.24093.PubMedCrossRef
33.
34.
go back to reference Harbuz M, Lightman S: Stress and the hypothalamo-pituitary-adrenal axis: acute, chronic and immunological activation. J Endocrinol. 1992, 134: 327-339. 10.1677/joe.0.1340327.PubMedCrossRef Harbuz M, Lightman S: Stress and the hypothalamo-pituitary-adrenal axis: acute, chronic and immunological activation. J Endocrinol. 1992, 134: 327-339. 10.1677/joe.0.1340327.PubMedCrossRef
35.
go back to reference Keller S, Weiss J, S. S, Miller N, Stein M: Stress-induced suppression of immunity in adrenalectomized rats. Science. 1983, 221: 1301-1304. 10.1126/science.6612346.PubMedCrossRef Keller S, Weiss J, S. S, Miller N, Stein M: Stress-induced suppression of immunity in adrenalectomized rats. Science. 1983, 221: 1301-1304. 10.1126/science.6612346.PubMedCrossRef
36.
go back to reference Homo-Delarche F, Fitzpatrick F, Christeff N, Nunez E, Bach J, Dardenne M: Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Mol Biol. 1991, 40: 619-637. 10.1016/0960-0760(91)90285-D.PubMedCrossRef Homo-Delarche F, Fitzpatrick F, Christeff N, Nunez E, Bach J, Dardenne M: Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Mol Biol. 1991, 40: 619-637. 10.1016/0960-0760(91)90285-D.PubMedCrossRef
37.
go back to reference VanItallie T: Stress: a risk factor for serious illness. Metabolism. 2002, 51: 40-45. 10.1053/meta.2002.33191.PubMedCrossRef VanItallie T: Stress: a risk factor for serious illness. Metabolism. 2002, 51: 40-45. 10.1053/meta.2002.33191.PubMedCrossRef
38.
go back to reference Holden R, Pakula I, Mooney P: An immunological model connecting the pathogenesis of stress, depression and carcinoma. Med Hypotheses. 1998, 51: 309-314. 10.1016/S0306-9877(98)90054-8.PubMedCrossRef Holden R, Pakula I, Mooney P: An immunological model connecting the pathogenesis of stress, depression and carcinoma. Med Hypotheses. 1998, 51: 309-314. 10.1016/S0306-9877(98)90054-8.PubMedCrossRef
39.
go back to reference Strange K, Kerr L, Andrews H, Emerman J, Weiberg J: Psychosocial stressors and mammary tumour growth: an animal model. Neurotoxicol Teratol. 2000, 22: 89-102. 10.1016/S0892-0362(99)00049-5.PubMedCrossRef Strange K, Kerr L, Andrews H, Emerman J, Weiberg J: Psychosocial stressors and mammary tumour growth: an animal model. Neurotoxicol Teratol. 2000, 22: 89-102. 10.1016/S0892-0362(99)00049-5.PubMedCrossRef
40.
go back to reference Hennighausen L, Robinson G: Signaling pathways in mammary gland development. Dev Cell. 2001, 1: 467-475. 10.1016/S1534-5807(01)00064-8.PubMedCrossRef Hennighausen L, Robinson G: Signaling pathways in mammary gland development. Dev Cell. 2001, 1: 467-475. 10.1016/S1534-5807(01)00064-8.PubMedCrossRef
41.
go back to reference Robinson G, Smith G, Gallahan D, Zimmerm A, Furth P, Hennighausen L: Understanding mammary gland development through the imbalanced expression of growth regulators. Dev Dyn. 1996, 206: 159-168. 10.1002/(SICI)1097-0177(199606)206:2<159::AID-AJA5>3.0.CO;2-H.PubMedCrossRef Robinson G, Smith G, Gallahan D, Zimmerm A, Furth P, Hennighausen L: Understanding mammary gland development through the imbalanced expression of growth regulators. Dev Dyn. 1996, 206: 159-168. 10.1002/(SICI)1097-0177(199606)206:2<159::AID-AJA5>3.0.CO;2-H.PubMedCrossRef
42.
go back to reference Gilbert S: Developmental Biology. 2006, Sunderland, MA: Sinauer Associates, 8 Gilbert S: Developmental Biology. 2006, Sunderland, MA: Sinauer Associates, 8
43.
go back to reference Majumder P, Joshi J, Banerjee M: Correlation between nuclear glucocorticoid receptor levels and casein gene expression in murine mammary gland in vitro. J Biol Chem. 1983, 258: 6793-6798.PubMed Majumder P, Joshi J, Banerjee M: Correlation between nuclear glucocorticoid receptor levels and casein gene expression in murine mammary gland in vitro. J Biol Chem. 1983, 258: 6793-6798.PubMed
44.
go back to reference Reichardt H, Horsch K, Grone H, Kolbus A, Beug H, Hynes N, Schutz G: Mammary gland development and lactation are controlled by different glucocorticoid receptor activities. Eur J Endocrinol. 2001, 145: 519-527. 10.1530/eje.0.1450519.PubMedCrossRef Reichardt H, Horsch K, Grone H, Kolbus A, Beug H, Hynes N, Schutz G: Mammary gland development and lactation are controlled by different glucocorticoid receptor activities. Eur J Endocrinol. 2001, 145: 519-527. 10.1530/eje.0.1450519.PubMedCrossRef
45.
go back to reference Wintermantel T, Bock D, Fleig V, Greiner E, Schutz G: The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production. Mol Endocrinol. 2005, 19: 340-349. 10.1210/me.2004-0068.PubMedCrossRef Wintermantel T, Bock D, Fleig V, Greiner E, Schutz G: The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production. Mol Endocrinol. 2005, 19: 340-349. 10.1210/me.2004-0068.PubMedCrossRef
46.
go back to reference Maina G, Bovenzi M, Palmas A, Larese Filon F: Associations between two job stress models and measures of salivary cortisol. Int Arch Occup Environ Health. 2009, 82: 1141-1150. 10.1007/s00420-009-0439-0.PubMedCrossRef Maina G, Bovenzi M, Palmas A, Larese Filon F: Associations between two job stress models and measures of salivary cortisol. Int Arch Occup Environ Health. 2009, 82: 1141-1150. 10.1007/s00420-009-0439-0.PubMedCrossRef
47.
go back to reference Chida Y, Steptoe A: Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol. 2009, 80: 265-278. 10.1016/j.biopsycho.2008.10.004.PubMedCrossRef Chida Y, Steptoe A: Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol. 2009, 80: 265-278. 10.1016/j.biopsycho.2008.10.004.PubMedCrossRef
48.
go back to reference Gonzalez A, Jenkins J, Steiner M, Fleming A: The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women. Psychoneuroendocrinology. 2009, 34: 76-86. 10.1016/j.psyneuen.2008.08.012.PubMedCrossRef Gonzalez A, Jenkins J, Steiner M, Fleming A: The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women. Psychoneuroendocrinology. 2009, 34: 76-86. 10.1016/j.psyneuen.2008.08.012.PubMedCrossRef
49.
go back to reference Elzinga B, Roelofs K, Tollenaar M, Bakvis P, van Pelt J, Spinhoven P: Diminished cortisol responses to psychosocial stress associated with lifetime adverse events: a study among healthy young subjects. Psychoneuroendocrinology. 2008, 33: 227-237. 10.1016/j.psyneuen.2007.11.004.PubMedCrossRef Elzinga B, Roelofs K, Tollenaar M, Bakvis P, van Pelt J, Spinhoven P: Diminished cortisol responses to psychosocial stress associated with lifetime adverse events: a study among healthy young subjects. Psychoneuroendocrinology. 2008, 33: 227-237. 10.1016/j.psyneuen.2007.11.004.PubMedCrossRef
50.
go back to reference Heim C, Newport D, Wagner D, Wilcox M, Miller A, Nemeroff C: The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety. 2002, 15: 117-125. 10.1002/da.10015.PubMedCrossRef Heim C, Newport D, Wagner D, Wilcox M, Miller A, Nemeroff C: The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety. 2002, 15: 117-125. 10.1002/da.10015.PubMedCrossRef
51.
go back to reference Henderson B, Ross R, Bernstein L: Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. Cancer Res. 1988, 48: 246-253.PubMed Henderson B, Ross R, Bernstein L: Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. Cancer Res. 1988, 48: 246-253.PubMed
52.
go back to reference Russo J, Hasan Lareef M, Balogh G, Guo S, Russo I: Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol. 2003, 87: 1-25. 10.1016/S0960-0760(03)00390-X.PubMedCrossRef Russo J, Hasan Lareef M, Balogh G, Guo S, Russo I: Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol. 2003, 87: 1-25. 10.1016/S0960-0760(03)00390-X.PubMedCrossRef
53.
go back to reference Simpson E: Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 2003, 86: 225-230. 10.1016/S0960-0760(03)00360-1.PubMedCrossRef Simpson E: Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 2003, 86: 225-230. 10.1016/S0960-0760(03)00360-1.PubMedCrossRef
54.
go back to reference Simpson E: Biology of aromatase in the mammary gland. J Mammary Gland Biol Neoplasia. 2000, 5: 251-258. 10.1023/A:1009590626450.PubMedCrossRef Simpson E: Biology of aromatase in the mammary gland. J Mammary Gland Biol Neoplasia. 2000, 5: 251-258. 10.1023/A:1009590626450.PubMedCrossRef
55.
go back to reference O'Neill JS, Elton RA, Miller WR: Aromatase activity in adipose tissue from breast quadrants: a link with tumour site. Br Med J (Clin Res Ed). 1988, 296: 741-743.CrossRef O'Neill JS, Elton RA, Miller WR: Aromatase activity in adipose tissue from breast quadrants: a link with tumour site. Br Med J (Clin Res Ed). 1988, 296: 741-743.CrossRef
56.
go back to reference Bulun S, Price T, Aitken J, Mahendroo M, Simpson E: A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab. 1993, 77: 1622-1628. 10.1210/jc.77.6.1622.PubMed Bulun S, Price T, Aitken J, Mahendroo M, Simpson E: A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab. 1993, 77: 1622-1628. 10.1210/jc.77.6.1622.PubMed
57.
go back to reference Brodie A, Lu Q, Nakamura J: Aromatase in the normal breast and breast cancer. J Steroid Biochem Mol Biol. 1997, 61: 281-286. 10.1016/S0960-0760(97)80024-6.PubMedCrossRef Brodie A, Lu Q, Nakamura J: Aromatase in the normal breast and breast cancer. J Steroid Biochem Mol Biol. 1997, 61: 281-286. 10.1016/S0960-0760(97)80024-6.PubMedCrossRef
58.
go back to reference Simpson E, Ackerman G, Smith M, Mendelson C: Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids. Proc Natl Acad Sci USA. 1981, 78: 5690-5694. 10.1073/pnas.78.9.5690.PubMedPubMedCentralCrossRef Simpson E, Ackerman G, Smith M, Mendelson C: Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids. Proc Natl Acad Sci USA. 1981, 78: 5690-5694. 10.1073/pnas.78.9.5690.PubMedPubMedCentralCrossRef
59.
go back to reference Schmidt M, Loffler G: Induction of aromatase in stromal vascular cells from human breast adipose tissue depends on cortisol and growth factors. FEBS Lett. 1994, 341: 177-181. 10.1016/0014-5793(94)80452-4.PubMedCrossRef Schmidt M, Loffler G: Induction of aromatase in stromal vascular cells from human breast adipose tissue depends on cortisol and growth factors. FEBS Lett. 1994, 341: 177-181. 10.1016/0014-5793(94)80452-4.PubMedCrossRef
60.
go back to reference Schmidt M, Loffler G: RU486 is a potent inhibitor of aromatase induction in human breast adipose tissue stromal cells. J Steroid Biochem Mol Biol. 1997, 60: 197-204. 10.1016/S0960-0760(96)00178-1.PubMedCrossRef Schmidt M, Loffler G: RU486 is a potent inhibitor of aromatase induction in human breast adipose tissue stromal cells. J Steroid Biochem Mol Biol. 1997, 60: 197-204. 10.1016/S0960-0760(96)00178-1.PubMedCrossRef
61.
go back to reference Romagnolo D, Annab L, Thompson T, Risinger J, Terry L, Barrett J, Afshari C: Estrogen upregulation of BRCA1 expression with no effect on localization. Mol Carcinog. 1998, 22: 102-109. 10.1002/(SICI)1098-2744(199806)22:2<102::AID-MC5>3.0.CO;2-O.PubMedCrossRef Romagnolo D, Annab L, Thompson T, Risinger J, Terry L, Barrett J, Afshari C: Estrogen upregulation of BRCA1 expression with no effect on localization. Mol Carcinog. 1998, 22: 102-109. 10.1002/(SICI)1098-2744(199806)22:2<102::AID-MC5>3.0.CO;2-O.PubMedCrossRef
62.
go back to reference Razandi M, Pedram A, Rosen E, Levin E: BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Mol Cell Biol. 2004, 24: 5900-5913. 10.1128/MCB.24.13.5900-5913.2004.PubMedPubMedCentralCrossRef Razandi M, Pedram A, Rosen E, Levin E: BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Mol Cell Biol. 2004, 24: 5900-5913. 10.1128/MCB.24.13.5900-5913.2004.PubMedPubMedCentralCrossRef
63.
go back to reference Antonova L, Mueller C: Hydrocortisone down-regulates the tumor suppressor gene BRCA1 in mammary cells: a possible molecular link between stress and breast cancer. Genes, Chromosomes Cancer. 2008, 47: 341-352. 10.1002/gcc.20538.PubMedCrossRef Antonova L, Mueller C: Hydrocortisone down-regulates the tumor suppressor gene BRCA1 in mammary cells: a possible molecular link between stress and breast cancer. Genes, Chromosomes Cancer. 2008, 47: 341-352. 10.1002/gcc.20538.PubMedCrossRef
64.
go back to reference Huizenga N, Koper J, de Lange P, Pols H, Stolk R, Burger H, Grobbee D, Brinkmann A, de Jong F, Lamberts S: A polymorphism in the glucocoritcoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab. 1998, 83: 144-151. 10.1210/jc.83.1.144.PubMed Huizenga N, Koper J, de Lange P, Pols H, Stolk R, Burger H, Grobbee D, Brinkmann A, de Jong F, Lamberts S: A polymorphism in the glucocoritcoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab. 1998, 83: 144-151. 10.1210/jc.83.1.144.PubMed
65.
go back to reference Di Blasio AM, van Rossum EF, Maestrini S, Berselli ME, Tagliaferri M, Podesta F, Koper JW, Liuzzi A, Lamberts SW: The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients. Clin Endocrinol (Oxf). 2003, 59: 68-74. 10.1046/j.1365-2265.2003.01798.x.CrossRef Di Blasio AM, van Rossum EF, Maestrini S, Berselli ME, Tagliaferri M, Podesta F, Koper JW, Liuzzi A, Lamberts SW: The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients. Clin Endocrinol (Oxf). 2003, 59: 68-74. 10.1046/j.1365-2265.2003.01798.x.CrossRef
66.
go back to reference Lin R, Wang W, Morris B: High penetrance, overweight, and glucocorticoid receptor variant: case-control study. Br Med J. 1999, 319: 1337-1338.CrossRef Lin R, Wang W, Morris B: High penetrance, overweight, and glucocorticoid receptor variant: case-control study. Br Med J. 1999, 319: 1337-1338.CrossRef
67.
go back to reference Lin R, Wang W, Morris B: Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension. 2003, 41: 404-407. 10.1161/01.HYP.0000055342.40301.DC.PubMedCrossRef Lin R, Wang W, Morris B: Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension. 2003, 41: 404-407. 10.1161/01.HYP.0000055342.40301.DC.PubMedCrossRef
68.
go back to reference Lin R, Wang W, Dalziel B, Caterson I, Morris B: Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. Obes Res. 2003, 11: 802-808. 10.1038/oby.2003.111.PubMedCrossRef Lin R, Wang W, Dalziel B, Caterson I, Morris B: Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. Obes Res. 2003, 11: 802-808. 10.1038/oby.2003.111.PubMedCrossRef
69.
go back to reference Curran JE, Lea RA, Rutherford S, Weinstein SR, Griffiths LR: Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer. Int J Cancer. 2001, 95: 271-275. 10.1002/1097-0215(20010720)95:4<271::AID-IJC1046>3.0.CO;2-D.PubMedCrossRef Curran JE, Lea RA, Rutherford S, Weinstein SR, Griffiths LR: Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer. Int J Cancer. 2001, 95: 271-275. 10.1002/1097-0215(20010720)95:4<271::AID-IJC1046>3.0.CO;2-D.PubMedCrossRef
70.
go back to reference Grippo A, Gerena D, Huang J, Kumar N, Shah M, Ughreja R, Sue Carter C: Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology. 2007, 32: 966-980. 10.1016/j.psyneuen.2007.07.004.PubMedPubMedCentralCrossRef Grippo A, Gerena D, Huang J, Kumar N, Shah M, Ughreja R, Sue Carter C: Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology. 2007, 32: 966-980. 10.1016/j.psyneuen.2007.07.004.PubMedPubMedCentralCrossRef
71.
go back to reference Dechambre R, Gosse C: Individual versus group caging of mice with grafted tumors. Cancer Res. 1973, 33: 140-144.PubMed Dechambre R, Gosse C: Individual versus group caging of mice with grafted tumors. Cancer Res. 1973, 33: 140-144.PubMed
72.
73.
go back to reference Weinberg J, Emerman J: Effects of psychosocial stressors on mouse mammary tumor growth. Brain Behav Immun. 1989, 3: 234-246. 10.1016/0889-1591(89)90039-1.PubMedCrossRef Weinberg J, Emerman J: Effects of psychosocial stressors on mouse mammary tumor growth. Brain Behav Immun. 1989, 3: 234-246. 10.1016/0889-1591(89)90039-1.PubMedCrossRef
74.
go back to reference Grimm M, Emerman J, Weinberg J: Effects of social housing condition and behavior on growth of the Shionogi mouse mammary carcinoma. Physiol Behav. 1996, 59: 633-642. 10.1016/0031-9384(95)02126-4.PubMedCrossRef Grimm M, Emerman J, Weinberg J: Effects of social housing condition and behavior on growth of the Shionogi mouse mammary carcinoma. Physiol Behav. 1996, 59: 633-642. 10.1016/0031-9384(95)02126-4.PubMedCrossRef
75.
go back to reference Hermes G, Delgado B, Tretiakova M, Cavigelli S, Krausz T, Conzen S, McClintock M: Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proc Natl Acad Sci USA. 2009, 106: 22393-22398. 10.1073/pnas.0910753106.PubMedPubMedCentralCrossRef Hermes G, Delgado B, Tretiakova M, Cavigelli S, Krausz T, Conzen S, McClintock M: Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proc Natl Acad Sci USA. 2009, 106: 22393-22398. 10.1073/pnas.0910753106.PubMedPubMedCentralCrossRef
76.
go back to reference Williams JB, Pang D, Delgado B, Kocherginsky M, Tretiakova M, Krausz T, Pan D, He J, McClintock M, Conzen S: A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation. Cancer Prev Res (Philia). 2009, 2: 850-861. 10.1158/1940-6207.CAPR-08-0238.CrossRef Williams JB, Pang D, Delgado B, Kocherginsky M, Tretiakova M, Krausz T, Pan D, He J, McClintock M, Conzen S: A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation. Cancer Prev Res (Philia). 2009, 2: 850-861. 10.1158/1940-6207.CAPR-08-0238.CrossRef
77.
go back to reference Rao U, Hammen C, Ortiz L, Chen L, Poland R: Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry. 2008, 64: 521-526. 10.1016/j.biopsych.2008.05.012.PubMedPubMedCentralCrossRef Rao U, Hammen C, Ortiz L, Chen L, Poland R: Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry. 2008, 64: 521-526. 10.1016/j.biopsych.2008.05.012.PubMedPubMedCentralCrossRef
78.
go back to reference Faravelli C, Amedei S, Rotella F, Faravelli L, Palla A, Consoli G, Ricca V, Batini S, Sauro C, Spiti A, Dell'osso M: Childhood trauma, dexamethasone suppression test and psychiatric symptoms: a trans-diagnostic approach. Psychol Med. 2010, 40: 2037-2048. 10.1017/S0033291710000115.PubMedCrossRef Faravelli C, Amedei S, Rotella F, Faravelli L, Palla A, Consoli G, Ricca V, Batini S, Sauro C, Spiti A, Dell'osso M: Childhood trauma, dexamethasone suppression test and psychiatric symptoms: a trans-diagnostic approach. Psychol Med. 2010, 40: 2037-2048. 10.1017/S0033291710000115.PubMedCrossRef
79.
go back to reference Gerritsen L, Geerlings M, Beekman A, Deeg D, Penninx B, Comijs H: Early and late life events and salivary cortisol in older persons. Psychol Med. 2010, 40: 1569-1578. 10.1017/S0033291709991863.PubMedCrossRef Gerritsen L, Geerlings M, Beekman A, Deeg D, Penninx B, Comijs H: Early and late life events and salivary cortisol in older persons. Psychol Med. 2010, 40: 1569-1578. 10.1017/S0033291709991863.PubMedCrossRef
80.
go back to reference Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen B, Watanabe Y: Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J Neurosci. 2010, 30: 15007-15018. 10.1523/JNEUROSCI.1436-10.2010.PubMedCrossRef Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen B, Watanabe Y: Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J Neurosci. 2010, 30: 15007-15018. 10.1523/JNEUROSCI.1436-10.2010.PubMedCrossRef
81.
go back to reference Enthoven L, de Kloet E, Oitzl M: Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care. Brain Res. 2008, 1217: 62-69. 10.1016/j.brainres.2008.04.009.PubMedCrossRef Enthoven L, de Kloet E, Oitzl M: Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care. Brain Res. 2008, 1217: 62-69. 10.1016/j.brainres.2008.04.009.PubMedCrossRef
82.
go back to reference Weaver I, Cervoni N, Champagne F, D'Alessio A, Sharma S, Seckl J, Dymov S, Szyf M, Meaney M: Epigenetic programming by maternal behavior. Nat Neurosci. 2004, 7: 847-854. 10.1038/nn1276.PubMedCrossRef Weaver I, Cervoni N, Champagne F, D'Alessio A, Sharma S, Seckl J, Dymov S, Szyf M, Meaney M: Epigenetic programming by maternal behavior. Nat Neurosci. 2004, 7: 847-854. 10.1038/nn1276.PubMedCrossRef
83.
go back to reference Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky P, Meaney M: Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science. 1997, 277: 1659-1662. 10.1126/science.277.5332.1659.PubMedCrossRef Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky P, Meaney M: Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science. 1997, 277: 1659-1662. 10.1126/science.277.5332.1659.PubMedCrossRef
84.
go back to reference Maina G, Palmas A, Bovenzi M, Larese Filonm F: Salivary cortisol and psychosocial hazards at work. Am J Ind Med. 2009, 52: 251-260. 10.1002/ajim.20659.PubMedCrossRef Maina G, Palmas A, Bovenzi M, Larese Filonm F: Salivary cortisol and psychosocial hazards at work. Am J Ind Med. 2009, 52: 251-260. 10.1002/ajim.20659.PubMedCrossRef
85.
go back to reference Borders AE, Grobman WA, Amsden LB, McDade TW, Sharp LK, Holl JL: The relationship between self-report and biomarkers of stress in low-income reproductiveage women. Am J Obstet Gynecol. 2010, 203: 1-8. 10.1016/j.ajog.2009.12.002.CrossRef Borders AE, Grobman WA, Amsden LB, McDade TW, Sharp LK, Holl JL: The relationship between self-report and biomarkers of stress in low-income reproductiveage women. Am J Obstet Gynecol. 2010, 203: 1-8. 10.1016/j.ajog.2009.12.002.CrossRef
86.
go back to reference Glaser R, Pearson G, Jones J, Hillhouse J, Kennedy S, Mao H, Kiecolt-Glaser J: Stress-related activation of Epstein-Barr virus. Brain Behav Immun. 1991, 5: 219-232. 10.1016/0889-1591(91)90018-6.PubMedCrossRef Glaser R, Pearson G, Jones J, Hillhouse J, Kennedy S, Mao H, Kiecolt-Glaser J: Stress-related activation of Epstein-Barr virus. Brain Behav Immun. 1991, 5: 219-232. 10.1016/0889-1591(91)90018-6.PubMedCrossRef
87.
go back to reference Palanza P: Animal models of anxiety and depression: how are females different?. Neurosci Biobehav Rev. 2001, 25: 219-233. 10.1016/S0149-7634(01)00010-0.PubMedCrossRef Palanza P: Animal models of anxiety and depression: how are females different?. Neurosci Biobehav Rev. 2001, 25: 219-233. 10.1016/S0149-7634(01)00010-0.PubMedCrossRef
88.
go back to reference Hasen NS, O'Leary KA, Auger AP, Schuler LA: Social isolation reduces mammary development, tumor incidence, and expression of epigenetic regulators in wild-type and p53-heterozygotic mice. Cancer Prev Res (Phila). 2010, 3: 620-629. 10.1158/1940-6207.CAPR-09-0225.CrossRef Hasen NS, O'Leary KA, Auger AP, Schuler LA: Social isolation reduces mammary development, tumor incidence, and expression of epigenetic regulators in wild-type and p53-heterozygotic mice. Cancer Prev Res (Phila). 2010, 3: 620-629. 10.1158/1940-6207.CAPR-09-0225.CrossRef
89.
go back to reference Amsterdam A, Tajima K, Sasson R: Cell-specific regulation of apoptosis by glucocorticoids. Biochem Pharmacol. 2002, 64: 843-850. 10.1016/S0006-2952(02)01147-4.PubMedCrossRef Amsterdam A, Tajima K, Sasson R: Cell-specific regulation of apoptosis by glucocorticoids. Biochem Pharmacol. 2002, 64: 843-850. 10.1016/S0006-2952(02)01147-4.PubMedCrossRef
90.
go back to reference Feng Z, Marti A, Jehn B, Altermatt H, Chicaiza G, Jaggi R: Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J Cell Biol. 1995, 131: 1095-1103. 10.1083/jcb.131.4.1095.PubMedCrossRef Feng Z, Marti A, Jehn B, Altermatt H, Chicaiza G, Jaggi R: Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J Cell Biol. 1995, 131: 1095-1103. 10.1083/jcb.131.4.1095.PubMedCrossRef
91.
go back to reference Moran T, Gray S, Mikosz C, Conzen S: The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res. 2000, 60: 867-872.PubMed Moran T, Gray S, Mikosz C, Conzen S: The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res. 2000, 60: 867-872.PubMed
92.
go back to reference Wu W, Pew T, Zou M, Pang D, Conzen S: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem. 2005, 280: 4117-4124. 10.1074/jbc.M411200200.PubMedCrossRef Wu W, Pew T, Zou M, Pang D, Conzen S: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem. 2005, 280: 4117-4124. 10.1074/jbc.M411200200.PubMedCrossRef
93.
go back to reference Filderman A, Bruckner A, Kacinski B, Deng N, Remold H: Macrophage colonystimulating factor (CSF-1) enhances invasiveness in CSF-1 receptorpositive carcinoma cell lines. Cancer Res. 1992, 52: 3661-3666.PubMed Filderman A, Bruckner A, Kacinski B, Deng N, Remold H: Macrophage colonystimulating factor (CSF-1) enhances invasiveness in CSF-1 receptorpositive carcinoma cell lines. Cancer Res. 1992, 52: 3661-3666.PubMed
94.
go back to reference Tangir J, Bonafe N, Gilmore-Hebert M, Henegariu O: SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004, 21: 477-483. 10.1007/s10585-004-4226-8.PubMedCrossRef Tangir J, Bonafe N, Gilmore-Hebert M, Henegariu O: SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004, 21: 477-483. 10.1007/s10585-004-4226-8.PubMedCrossRef
95.
go back to reference Lien H, Lu Y, Cheng A, Chang W, Jeng Y, Kuo Y, Huang C, Chang K, Yao Y: Differential expression of glucocorticoid receptor in human breast tissues and related neoplasms. J Pathol. 2006, 209: 317-327. 10.1002/path.1982.PubMedCrossRef Lien H, Lu Y, Cheng A, Chang W, Jeng Y, Kuo Y, Huang C, Chang K, Yao Y: Differential expression of glucocorticoid receptor in human breast tissues and related neoplasms. J Pathol. 2006, 209: 317-327. 10.1002/path.1982.PubMedCrossRef
96.
go back to reference Lippman M, Bolan G, Huff K: The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 1976, 36: 4602-4609.PubMed Lippman M, Bolan G, Huff K: The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 1976, 36: 4602-4609.PubMed
97.
go back to reference Goya L, Maiyar A, Ge Y, Firestone G: Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factoralpha. Mol Endocrinol. 1993, 7: 1121-1132. 10.1210/me.7.9.1121.PubMed Goya L, Maiyar A, Ge Y, Firestone G: Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factoralpha. Mol Endocrinol. 1993, 7: 1121-1132. 10.1210/me.7.9.1121.PubMed
98.
go back to reference Rocha Viegas L, Hoijman E, Beato M, Pecci A: Mechanisms involved in tissuespecific apoptosis regulated by glucocorticoids. J Steroid Biochem Mol Biol. 2008, 109: 273-278. 10.1016/j.jsbmb.2008.03.007.CrossRef Rocha Viegas L, Hoijman E, Beato M, Pecci A: Mechanisms involved in tissuespecific apoptosis regulated by glucocorticoids. J Steroid Biochem Mol Biol. 2008, 109: 273-278. 10.1016/j.jsbmb.2008.03.007.CrossRef
99.
go back to reference Moutsatsou P, Papavassiliou A: The glucocorticoid receptor signalling in breast cancer. J Cell Mol Med. 2008, 12: 145-163. 10.1111/j.1582-4934.2007.00177.x.PubMedCrossRef Moutsatsou P, Papavassiliou A: The glucocorticoid receptor signalling in breast cancer. J Cell Mol Med. 2008, 12: 145-163. 10.1111/j.1582-4934.2007.00177.x.PubMedCrossRef
100.
go back to reference Wu W, Zou M, Brickley D, Pew T, Conzen S: Glucocorticoid receptor activation signals through Forkhead Transcription Factor 3a in breast cancer cells. Mol Endocrinol. 2006, 20: 2304-2314. 10.1210/me.2006-0131.PubMedCrossRef Wu W, Zou M, Brickley D, Pew T, Conzen S: Glucocorticoid receptor activation signals through Forkhead Transcription Factor 3a in breast cancer cells. Mol Endocrinol. 2006, 20: 2304-2314. 10.1210/me.2006-0131.PubMedCrossRef
101.
go back to reference Messmer U, Pereda-Fernandez C, Manderscheid M, Pfeilschifter J: Dexamethasone inhibits TNFa-induced apoptosis and IAP protein downregulation in MCF-7 cells. Br J Pharmacol. 2001, 133: 467-476. 10.1038/sj.bjp.0704093.PubMedPubMedCentralCrossRef Messmer U, Pereda-Fernandez C, Manderscheid M, Pfeilschifter J: Dexamethasone inhibits TNFa-induced apoptosis and IAP protein downregulation in MCF-7 cells. Br J Pharmacol. 2001, 133: 467-476. 10.1038/sj.bjp.0704093.PubMedPubMedCentralCrossRef
102.
go back to reference Webster Marketon J, Glaser R: Stress hormones and immune function. Cell Immunol. 2008, 252: 16-26. 10.1016/j.cellimm.2007.09.006.PubMedCrossRef Webster Marketon J, Glaser R: Stress hormones and immune function. Cell Immunol. 2008, 252: 16-26. 10.1016/j.cellimm.2007.09.006.PubMedCrossRef
103.
go back to reference Yang E, Glaser R: Stress-induced immunomodulation: implications for tumorigenesis. Brain Behav Immun. 2003, 17: S37-S40. 10.1016/S0889-1591(02)00064-8.PubMedCrossRef Yang E, Glaser R: Stress-induced immunomodulation: implications for tumorigenesis. Brain Behav Immun. 2003, 17: S37-S40. 10.1016/S0889-1591(02)00064-8.PubMedCrossRef
104.
go back to reference Kiecolt-Glaser J, Stephens R, Lipetz P, Speicher C, Glaser R: Distress and DNA repair in human lymphocytes. J Behav Med. 1985, 8: 311-320. 10.1007/BF00848366.PubMedCrossRef Kiecolt-Glaser J, Stephens R, Lipetz P, Speicher C, Glaser R: Distress and DNA repair in human lymphocytes. J Behav Med. 1985, 8: 311-320. 10.1007/BF00848366.PubMedCrossRef
105.
go back to reference Glaser R, Kiecolt-Glaser J, Stout J, Tarr K, Speicher C, Holliday J: Stress-related impairments in cellular immunity. Psychiatry Res. 1985, 16: 233-239. 10.1016/0165-1781(85)90111-8.PubMedCrossRef Glaser R, Kiecolt-Glaser J, Stout J, Tarr K, Speicher C, Holliday J: Stress-related impairments in cellular immunity. Psychiatry Res. 1985, 16: 233-239. 10.1016/0165-1781(85)90111-8.PubMedCrossRef
106.
go back to reference Cohen L, Marshall GJ, Cheng L, Sandeep A, Wei Q: DNA repair capacity in healthy medical students during and after exam stress. J Behav Med. 2000, 23: 531-544. 10.1023/A:1005503502992.PubMedCrossRef Cohen L, Marshall GJ, Cheng L, Sandeep A, Wei Q: DNA repair capacity in healthy medical students during and after exam stress. J Behav Med. 2000, 23: 531-544. 10.1023/A:1005503502992.PubMedCrossRef
107.
go back to reference Fischman H, Pero R, Kelly D: Psychogenic stress induces chromosomal and DNA damage. Int J Neurosci. 1996, 84: 219-227. 10.3109/00207459608987267.PubMedCrossRef Fischman H, Pero R, Kelly D: Psychogenic stress induces chromosomal and DNA damage. Int J Neurosci. 1996, 84: 219-227. 10.3109/00207459608987267.PubMedCrossRef
108.
go back to reference Sacharczuk M, Jaszczak K, Sadowski B: Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia. Mutat Res. 2003, 535: 95-102. 10.1016/S1383-5718(02)00290-5.PubMedCrossRef Sacharczuk M, Jaszczak K, Sadowski B: Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia. Mutat Res. 2003, 535: 95-102. 10.1016/S1383-5718(02)00290-5.PubMedCrossRef
109.
go back to reference Adachi S, Kawamura K, Takemoto K: Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress. Cancer Res. 1993, 53: 4153-4155.PubMed Adachi S, Kawamura K, Takemoto K: Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress. Cancer Res. 1993, 53: 4153-4155.PubMed
110.
go back to reference Flint M, Baum A, Chambers W, Jenkins F: Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Psychoneuroendocrinology. 2007, 32: 470-479. 10.1016/j.psyneuen.2007.02.013.PubMedCrossRef Flint M, Baum A, Chambers W, Jenkins F: Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Psychoneuroendocrinology. 2007, 32: 470-479. 10.1016/j.psyneuen.2007.02.013.PubMedCrossRef
111.
go back to reference Miki Y, Swensen J, Shattuck-Eidens D, Futreal P, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, et al: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994, 266: 66-71. 10.1126/science.7545954.PubMedCrossRef Miki Y, Swensen J, Shattuck-Eidens D, Futreal P, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, et al: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994, 266: 66-71. 10.1126/science.7545954.PubMedCrossRef
112.
go back to reference Easton D, Ford D, Bishop D: Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet. 1995, 56: 265-271.PubMedPubMedCentralCrossRef Easton D, Ford D, Bishop D: Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet. 1995, 56: 265-271.PubMedPubMedCentralCrossRef
113.
go back to reference Thompson M, Jensen R, Obermiller P, Page D, Holt J: Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet. 1995, 9: 444-450. 10.1038/ng0495-444.PubMedCrossRef Thompson M, Jensen R, Obermiller P, Page D, Holt J: Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet. 1995, 9: 444-450. 10.1038/ng0495-444.PubMedCrossRef
114.
go back to reference Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG: Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila). 2010, 3: 48-61. 10.1158/1940-6207.CAPR-09-0078.CrossRef Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG: Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila). 2010, 3: 48-61. 10.1158/1940-6207.CAPR-09-0078.CrossRef
Metadata
Title
Stress and breast cancer: from epidemiology to molecular biology
Authors
Lilia Antonova
Kristan Aronson
Christopher R Mueller
Publication date
01-04-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 2/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2836

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