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Breast Cancer Research
Published in: Breast Cancer Research 1/2011

01-02-2011 | Letter

Circulating microRNAs: promising breast cancer Biomarkers

Authors: Helen M Heneghan, Nicola Miller, Michael J Kerin

Published in: Breast Cancer Research | Issue 1/2011

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Excerpt

We read with interest the recent article by Roth and colleagues [1] reporting the findings of altered tumorspecific microRNAs (miRNAs) in sera of breast cancer patients. This report further substantiates emerging data suggesting that blood-based miRNAs have immense potential as novel non-invasive cancer biomarkers. However, we have several concerns regarding the authors' study. …
Literature
1.
Roth C, Rack B, Muller V, Janni W, Pantel K, Schwarzenbach H: Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res. 2010, 12: R90-10.1186/bcr2766.CrossRefPubMedPubMedCentral
2.
Heneghan HM, Miller N, Lowery AJ, Sweeney KJ, Newell J, Kerin MJ: Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann Surg. 2010, 251: 499-505. 10.1097/SLA.0b013e3181cc939f.CrossRefPubMed
3.
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5.
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 2008, 105: 10513-10518. 10.1073/pnas.0804549105.CrossRefPubMedPubMedCentral
Metadata
Title
Circulating microRNAs: promising breast cancer Biomarkers
Authors
Helen M Heneghan
Nicola Miller
Michael J Kerin
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2798

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