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Breast Cancer Research
Published in: Breast Cancer Research 6/2010

01-12-2010 | Review

Breast cancer metastasis to the bone: mechanisms of bone loss

Authors: Yu-Chi Chen, Donna M Sosnoski, Andrea M Mastro

Published in: Breast Cancer Research | Issue 6/2010

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Abstract

Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone remodeling process and causing bone degradation. Osteolytic lesions are the end result of osteoclast activity; however, osteoclast differentiation and activation are mediated by osteoblast production of RANKL (receptor activator for NFκB ligand) and several osteoclastogenic cytokines. Osteoblasts themselves are negatively affected by cancer cells as evidenced by an increase in apoptosis and a decrease in proteins required for new bone formation. Thus, bone loss is due to both increased activation of osteoclasts and suppression of osteoblasts. This review summarizes the current understanding of the osteolytic mechanisms of bone metastases, including a discussion of current therapies.
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Metadata
Title
Breast cancer metastasis to the bone: mechanisms of bone loss
Authors
Yu-Chi Chen
Donna M Sosnoski
Andrea M Mastro
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2781

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