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Breast Cancer Research
Published in: Breast Cancer Research 2/2001

01-04-2001 | Commentary

The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer

Authors: Roberto Chiarle, Michele Pagano, Giorgio Inghirami

Published in: Breast Cancer Research | Issue 2/2001

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Abstract

p27 is an inhibitor of cyclin dependent kinase involved in the regulation of the cell cycle. In this commentary we discuss the current knowledge on p27 in breast cancer and its significance in predicting the outcome. p27 protein levels are high in most cases of breast carcinomas, are correlated with the levels of cyclin D1 and estrogen receptor, and could be a useful predictor of survival, because they are low in aggressive carcinomas. Immunodetection of p27 in breast tumors could be useful in the assessment of prognosis, especially in those cases in which the commonly used parameters are insufficient, and might ultimately influence the therapy of this disease.
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Metadata
Title
The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer
Authors
Roberto Chiarle
Michele Pagano
Giorgio Inghirami
Publication date
01-04-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 2/2001
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr277

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