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Breast Cancer Research
Published in: Breast Cancer Research 1/2009

Open Access 01-06-2009 | Research article

Prognostic impact of human epidermal growth factor-like receptor 2 and hormone receptor status in inflammatory breast cancer (IBC): analysis of 2,014 IBC patient cases from the California Cancer Registry

Authors: Jason A Zell, Walter Y Tsang, Thomas H Taylor, Rita S Mehta, Hoda Anton-Culver

Published in: Breast Cancer Research | Issue 1/2009

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Abstract

Introduction

Inflammatory breast cancer (IBC) is an aggressive form of breast cancer associated with overexpression of Her2/Neu (human epidermal growth factor-like receptor 2 (HER2)) and poor survival. We investigated survival differences for IBC patient cases based on hormone receptor status and HER2 receptor status using data from the California Cancer Registry, as contrasted with locally advanced breast cancer (LABC), metastatic breast cancer (MBC) and non-T4 breast cancer.

Methods

A case-only analysis of 80,099 incident female breast cancer patient cases in the California Cancer Registry during 1999 to 2003 was performed, with follow-up through March 2007. Overall survival (OS) and breast cancer-specific survival (BC-SS) were analyzed using Kaplan–Meier methods and Cox proportional hazards ratios.

Results

A total of 2,014 IBC, 1,268 LABC, 3,059 MBC, and 73,758 non-T4 breast cancer patient cases were identified. HER2+ was associated with advanced tumor stage (P < 0.0001). IBC patient cases were more likely to be HER2+ (40%) and less likely to be hormone receptor-positive (HmR+) (59%) compared with LABC (35% and 69%, respectively), MBC (35% and 74%), and non-T4 patient cases (22% and 82%). HmR+ status was associated with improved OS and BC-SS for each breast cancer subtype after adjustment for clinically relevant factors. In multivariate analysis, HER2+ (versus HER2-) status was associated with poor BC-SS for non-T4 patient cases (hazards ratio = 1.16, 95% confidence interval 1.05 to 1.28) and had a borderline significant association with improved BC-SS for IBC (hazards ratio = 0.82, 95% confidence interval = 0.68 to 0.99).

Conclusions

Despite an association with advanced tumor stage, HER2+ status is not an independent adverse prognostic factor for survival among IBC patient cases.
Appendix
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Literature
1.
Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, Morrow M: AJCC (American Joint Committee on Cancer) Cancer Staging Manual. 2002, New York: Springer-Verlag, 6CrossRef
2.
Hance KW, Anderson WF, Devesa SS, Young HA, Levine PH: Trends in inflammatory breast carcinoma incidence and survival: the Surveillance, Epidemiology, and End Results Program at the National Cancer Institute. J Natl Cancer Inst. 2005, 97: 966-975.CrossRefPubMedPubMedCentral
3.
Tai P, Yu E, Shiels R, Pacella J, Jones K, Sadikov E, Mahmood S: Short- and long-term cause-specific survival of patients with inflammatory breast cancer. BMC Cancer. 2005, 5: 1-10. 10.1186/1471-2407-5-1.CrossRef
4.
Buzdar AU, Singletary SE, Booser DJ, Frye DK, Wasaff B, Hortobagyi GN: Combined modality treatment of stage III and inflammatory breast cancer. M.D. Anderson Cancer Center experience. Surg Oncol Clin N Am. 1995, 4: 715-734.PubMed
5.
Gonzalez-Angulo AM, Hennessy BT, Broglio K, Meric-Bernstam F, Cristofanilli M, Giordano SH, Buchholz TA, Sahin A, Singletary SE, Buzdar AU, Hortobagyi GN: Trends for inflammatory breast cancer: is survival improving?. Oncologist. 2007, 12: 904-912. 10.1634/theoncologist.12-8-904.CrossRefPubMed
6.
Aziz SA, Pervez S, Khan S, Kayani N, Azam SI, Rahbar MH: Case control study of prognostic markers and disease outcome in inflammatory carcinoma breast: a unique clinical experience. Breast J. 2001, 7: 398-404. 10.1046/j.1524-4741.2001.07604.x.CrossRefPubMed
7.
8.
Parton M, Dowsett M, Ashley S, Hills M, Lowe F, Smith IE: High incidence of HER-2 positivity in inflammatory breast cancer. Breast. 2004, 13: 97-103. 10.1016/j.breast.2003.08.004.CrossRefPubMed
9.
Sawaki M, Ito Y, Akiyama F, Tokudome N, Horii R, Mizunuma N, Takahashi S, Horikoshi N, Imai T, Nakao A, Kasumi F, Sakamoto G, Hatake K: High prevalence of HER-2/neu and p53 overexpression in inflammatory breast cancer. Breast Cancer. 2006, 13: 172-178. 10.2325/jbcs.13.172.CrossRefPubMed
10.
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987, 235: 177-182. 10.1126/science.3798106.CrossRefPubMed
11.
Caggiano V, Brown M, Bauer K, Tsodikov A, Parice C: Incidence, risk factors and survival among triple negative phenotypic (estrogen receptor, progesterone receptor, and HER2 negative) breast cancers in California, 1999–2003. Breast Cancer Res Treat. 2006, 100: S275-
12.
Brown M, Tsodikov A, Bauer KR, Parise CA, Caggiano V: The role of human epidermal growth factor receptor 2 in the survival of women with estrogen and progesterone receptor-negative, invasive breast cancer: the California Cancer Registry, 1999–2004. Cancer. 2008, 112: 737-747. 10.1002/cncr.23243.CrossRefPubMed
13.
Dawood S, Broglio K, Gong Y, Yang WT, Cristofanilli M, Kau SW, Meric-Bernstam F, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM: Prognostic significance of HER-2 status in women with inflammatory breast cancer. Cancer. 2008, 112: 1905-1911. 10.1002/cncr.23350.CrossRefPubMedPubMedCentral
14.
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE, Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, Yothers G, Jenkins RB, Brown AM, Dakhil SR, Mamounas EP, Lingle WL, Klein PM, Ingle JN, Wolmark N: Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005, 353: 1673-1684. 10.1056/NEJMoa052122.CrossRefPubMed
15.
Smith I, Procter M, Gelber RD, Guillaume S, Feyereislova A, Dowsett M, Goldhirsch A, Untch M, Mariani G, Baselga J, Kaufmann M, Cameron D, Bell R, Bergh J, Coleman R, Wardley A, Harbeck N, Lopez RI, Mallmann P, Gelmon K, Wilcken N, Wist E, Sanchez Rovira P, Piccart-Gebhart MJ: 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet. 2007, 369: 29-36. 10.1016/S0140-6736(07)60028-2.CrossRefPubMed
16.
Parikh-Patel A, Bates JH, Campleman S: Colorectal cancer stage at diagnosis by socioeconomic and urban/rural status in California, 1988–2000. Cancer. 2006, 107: 1189-1195. 10.1002/cncr.22016.CrossRefPubMed
17.
Cancer Surveillance Section: Cancer Reporting in California: Standards for Automated Reporting. California Cancer Reporting System Standards. 1997, Sacramento, CA: California Department of Health Services, II:
18.
Cancer Surveillance Section: Cancer Reporting in California: Data Standards for Regional Registries and Calfornia Cancer Registry. California Cancer Reporting Standards. 1997, Sacramento, CA: California Department of Health Services, III:
19.
ICD-9-CM: International Classification of Diseases. 9th revision. 1997, Los Angeles: Practice Management Information Corp, [Clinical Modification. 5th edition, color coded. Vols 1, 2, 3.]
20.
Fritz A, Percy C, Jack A, Shanmugaratnam K, Parkin DM, Whelan S: International Classification of Diseases for Oncology. 2000, Geneva: World Health Organization, 3
21.
Yost K, Perkins C, Cohen R, Morris C, Wright W: Socioeconomic status and breast cancer incidence in California for different race/ethnic groups. Cancer Causes Control. 2001, 12: 703-711. 10.1023/A:1011240019516.CrossRefPubMed
22.
Ou SH, Zell JA, Ziogas A, Anton-Culver H: Low socioeconomic status is a poor prognostic factor for survival in stage I nonsmall cell lung cancer and is independent of surgical treatment, race, and marital status. Cancer. 2008, 112: 2011-2020. 10.1002/cncr.23397.CrossRefPubMed
23.
Zell JA, Cinar P, Mobasher M, Ziogas A, Meyskens FL, Anton-Culver H: Survival for patients with invasive cutaneous melanoma among ethnic groups: the effects of socioeconomic status and treatment. J Clin Oncol. 2008, 26: 66-75. 10.1200/JCO.2007.12.3604.CrossRefPubMed
24.
Zell JA, Rhee JM, Ziogas A, Lipkin SM, Anton-Culver H: Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in California. Cancer Epidemiol Biomarkers Prev. 2007, 16: 546-552. 10.1158/1055-9965.EPI-06-0893.CrossRefPubMed
25.
Turpin E, Bieche I, Bertheau P, Plassa LF, Lerebours F, de Roquancourt A, Olivi M, Espie M, Marty M, Lidereau R, Vidaud M, de The H: Increased incidence of ERBB2 overexpression and TP53 mutation in inflammatory breast cancer. Oncogene. 2002, 21: 7593-7597. 10.1038/sj.onc.1205932.CrossRefPubMed
26.
Maalej M, Frikha H, Ben Salem S, Daoud J, Bouaouina N, Ben Abdallah M, Ben Romdhane K: Breast cancer in Tunisia: clinical and epidemiological study. Bull Cancer. 1999, 86: 302-306.PubMed
27.
Charafe-Jauffret E, Mrad K, Intidhar Labidi S, Ben Hamida A, Ben Romdhane K, Ben Abdallah M, Ginestier C, Esterni B, Birnbaum D, Ben Ayed F, Xerri L, Viens P, Mezlini A, Jacquemier J: Inflammatory breast cancers in Tunisia and France show similar immunophenotypes. Breast. 2007, 16: 352-358. 10.1016/j.breast.2007.01.002.CrossRefPubMed
28.
Shirakawa K, Kobayashi H, Heike Y, Kawamoto S, Brechbiel MW, Kasumi F, Iwanaga T, Konishi F, Terada M, Wakasugi H: Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft. Cancer Res. 2002, 62: 560-566.PubMed
29.
Tomlinson JS, Alpaugh ML, Barsky SH: An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Cancer Res. 2001, 61: 5231-5241.PubMed
30.
Cabioglu N, Gong Y, Islam R, Broglio KR, Sneige N, Sahin A, Gonzalez-Angulo AM, Morandi P, Bucana C, Hortobagyi GN, Cristofanilli M: Expression of growth factor and chemokine receptors: new insights in the biology of inflammatory breast cancer. Ann Oncol. 2007, 18: 1021-1029. 10.1093/annonc/mdm060.CrossRefPubMed
31.
Nguyen DM, Sam K, Tsimelzon A, Li X, Wong H, Mohsin S, Clark GM, Hilsenbeck SG, Elledge RM, Allred DC, O'Connell P, Chang JC: Molecular heterogeneity of inflammatory breast cancer: a hyperproliferative phenotype. Clin Cancer Res. 2006, 12: 5047-5054. 10.1158/1078-0432.CCR-05-2248.CrossRefPubMed
32.
Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P, Fox SB, Harris AL, van Marck EA: Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression. Br J Cancer. 2003, 88: 718-725. 10.1038/sj.bjc.6600807.CrossRefPubMedPubMedCentral
33.
van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD: RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res. 2000, 60: 5832-5838.PubMed
34.
Kleer CG, Zhang Y, Pan Q, van Golen KL, Wu ZF, Livant D, Merajver SD: WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene. 2002, 21: 3172-3180. 10.1038/sj.onc.1205462.CrossRefPubMed
35.
Cristofanilli M, Valero V, Buzdar AU, Kau SW, Broglio KR, Gonzalez-Angulo AM, Sneige N, Islam R, Ueno NT, Buchholz TA, Singletary SE, Hortobagyi GN: Inflammatory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique disease. Cancer. 2007, 110: 1436-1444. 10.1002/cncr.22927.CrossRefPubMed
36.
Berry DA, Cirrincione C, Henderson IC, Citron ML, Budman DR, Goldstein LJ, Martino S, Perez EA, Muss HB, Norton L, Hudis C, Winer EP: Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA. 2006, 295: 1658-1667. 10.1001/jama.295.14.1658.CrossRefPubMedPubMedCentral
37.
Mehta RS: Dose-dense and/or metronomic schedules of specific chemotherapies consolidate the chemosensitivity of triple-negative breast cancer: a step toward reversing triple-negative paradox. J Clin Oncol. 2008, 26: 3286-3288. 10.1200/JCO.2008.17.1116.CrossRefPubMed
38.
Gluz O, Nitz UA, Harbeck N, Ting E, Kates R, Herr A, Lindemann W, Jackisch C, Berdel WE, Kirchner H, Metzner B, Werner F, Schutt G, Frick M, Poremba C, Diallo-Danebrock R, Mohrmann S: Triple-negative high-risk breast cancer derives particular benefit from dose intensification of adjuvant chemotherapy: results of WSG AM-01 trial. Ann Oncol. 2008, 19: 861-870. 10.1093/annonc/mdm551.CrossRefPubMed
39.
Ellis GK, Green SJ, Russell CA, Royce ME, Perez EA, Livingston RB: SWOG a randomized phase III comparison of standard doxorubicin (A) and cyclophosphamide (C) followed by weekly paclitaxel (T) versus weekly doxorubicin and daily oral cyclophosphamide plus G-CSF (G) followed by weekly paclitaxel as neoadjuvant therapy for inflammatory and locally advanced breast cancer. J Clin Oncol. 0012, 24: LBA537-(abstract).
40.
Sparano JA, Wang M, Martino S, Jones V, Perez EA, Saphner T, Wolff AC, Sledge GW, Wood WC, Davidson NE: Weekly paclitaxel in the adjuvant treatment of breast cancer. N Engl J Med. 2008, 358: 1663-1671. 10.1056/NEJMoa0707056.CrossRefPubMedPubMedCentral
41.
Mehta RS, Schubbert T, Jackson D, Hsiang D, Butler J: Pathologic complete response following paclitaxel (cremophor or albumin bound) + carboplatin +/- trastuzumab +/- bevacizumab sequenced after in vivo chemosensitivity-adapted dose-dense doxorubicin-cyclophophamide in inflammatory breast cancer [abstract 5066]. Proceedings of the San Antonio Breast Conference; Dec. 13–16. 2007, , San Antonio, TX
42.
Metadata
Title
Prognostic impact of human epidermal growth factor-like receptor 2 and hormone receptor status in inflammatory breast cancer (IBC): analysis of 2,014 IBC patient cases from the California Cancer Registry
Authors
Jason A Zell
Walter Y Tsang
Thomas H Taylor
Rita S Mehta
Hoda Anton-Culver
Publication date
01-06-2009
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2009
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2225

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