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Published in:

01-10-2008 | Review

Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer

Authors: Charles Swanton, Zoltan Szallasi, James D Brenton, Julian Downward

Published in: Breast Cancer Research | Issue 5/2008

Abstract

The widespread introduction of high throughput RNA interference screening technology has revealed tumour drug sensitivity pathways to common cytotoxics such as paclitaxel, doxorubicin and 5-fluorouracil, targeted agents such as trastuzumab and inhibitors of AKT and Poly(ADP-ribose) polymerase (PARP) as well as endocrine therapies such as tamoxifen. Given the limited power of microarray signatures to predict therapeutic response in associative studies of small clinical trial cohorts, the use of functional genomic data combined with expression or sequence analysis of genes and microRNAs implicated in drug response in human tumours may provide a more robust method to guide adjuvant treatment strategies in breast cancer that are transferable across different expression platforms and patient cohorts.

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Title: Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer
Authors: Charles Swanton
Zoltan Szallasi
James D Brenton
Julian Downward
Publication date: 01-10-2008
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 5/2008
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2159

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