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Breast Cancer Research
Published in: Breast Cancer Research 5/2008

01-10-2008 | Editorial

The evolving role of oestrogen receptor β in clinical breast cancer

Author: Valerie Speirs

Published in: Breast Cancer Research | Issue 5/2008

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Abstract

Controversy surrounds the potential clinical importance of oestrogen receptor (ER)β in breast cancer, and three recent papers have sought to resolve this. In the present issue of Breast Cancer Research Novelli and colleagues explored the significance of ERβ1 expression in 936 breast cancer patients, and they showed diverse relationships according to lymph node status. A second paper examined 442 breast cancers in which ERβ1 was an independent predictor of recurrence, disease-free survival and overall survival. Finally a third paper showed that ERβ2 was a powerful prognostic indicator in 757 breast cancers but this was dependent on cellular location, with nuclear ERβ2 expression predicting good survival whilst cytoplasmic expression predicted worse outcome. These papers point to a clinical role for ERβ in breast cancer and shall be discussed.
Literature
1.
Novelli F, Milella M, Melucci E, Di Benedetto A, Sperduti I, Perrone-Donnorso R, Perrachio L, Venturo I, Nistico C, Fabi A, Buglioni S, Giorgio Natali P, Mottolese M: A divergent role for estrogen receptor beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study. Breast Cancer Res. 2008, 10: R74-10.1186/bcr2139.CrossRefPubMedPubMedCentral
2.
Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PT, Groome NP, Speirs V: Nuclear and cytoplasmic expression of ERβ1, ERβ2, and ERβ5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res. 2008, 14: 5228-5235. 10.1158/1078-0432.CCR-07-4528.CrossRefPubMed
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Honma N, Horii R, Iwase T, Saji S, Younes M, Takubo K, Matsuura M, Ito Y, Akiyama F, Sakamoto G: Clinical importance of estrogen receptor-β evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol. 2008, 26: 3727-3734. 10.1200/JCO.2007.14.2968.CrossRefPubMed
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Skliris GP, Leygue E, Curtis-Snell L, Watson PH, Murphy LC: Expression of oestrogen receptor-β in oestrogen receptor-α negative human breast tumours. Br J Cancer. 2006, 95: 616-626. 10.1038/sj.bjc.6603295.CrossRefPubMedPubMedCentral
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Nakopoulou L, Lazaris AC, Panayotopoulou EG, Giannopoulou I, Givalos N, Markaki S, Keramopoulos A: The favourable prognostic value of oestrogen receptor β immunohistochemical expression in breast cancer. J Clin Pathol. 2004, 57: 523-528. 10.1136/jcp.2003.008599.CrossRefPubMedPubMedCentral
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Saji S, Hirose M, Toi M: Clinical significance of estrogen receptor β in breast cancer. Cancer Chemother Pharmacol. 2005, 56 (Suppl 1): 21-26. 10.1007/s00280-005-0107-3.CrossRefPubMed
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Jensen EV, Cheng G, Palmieri C, Saji S, Mäkelä S, Van Noorden S, Wahlström T, Warner M, Coombes RC, Gustafsson JA: Estrogen receptors and proliferation markers in primary and recurrent breast cancer. Proc Natl Acad Sci USA. 2001, 98: 15197-15202. 10.1073/pnas.211556298.CrossRefPubMedPubMedCentral
8.
Skliris GP, Parkes AT, Limer JL, Burdall SE, Carder PJ, Speirs V: Evaluation of seven oestrogen receptor β antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue. J Pathol. 2002, 197: 155-162. 10.1002/path.1077.CrossRefPubMed
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Shaaban AM, O'Neill PA, Davies MP, Sibson R, West CR, Smith PH, Foster CS: Declining estrogen receptor-β expression defines malignant progression of human breast neoplasia. Am J Surg Pathol. 2003, 27: 1502-1512. 10.1097/00000478-200302000-00021.CrossRefPubMed
Metadata
Title
The evolving role of oestrogen receptor β in clinical breast cancer
Author
Valerie Speirs
Publication date
01-10-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2140

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