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Breast Cancer Research
Published in: Breast Cancer Research 2/2008

01-05-2008 | Poster presentation

p53β isoform modulates differentially p53 transcriptional activity in response to stress

Authors: K Fernandes, JC Bourdon

Published in: Breast Cancer Research | Special Issue 2/2008

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Excerpt

We recently established that the p53 gene expresses nine different p53 protein isoforms. The p53 isoforms bind preferentially to some p53-responsive promoters and modulate differentially p53 transcriptional activity [1]. We characterized further p53β activity. p53β is differentially recruited to p21 and bax promoters in the absence or in the presence of DNA-damaging drugs. …
Literature
1.
Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP, Saville MK, Lane DP: p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 2005, 19: 2122-2137. 10.1101/gad.1339905.CrossRefPubMedPubMedCentral
Metadata
Title
p53β isoform modulates differentially p53 transcriptional activity in response to stress
Authors
K Fernandes
JC Bourdon
Publication date
01-05-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1896

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