Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 2/2008

01-04-2008 | Editorial

Breast cancer surface receptors predict risk for developing brain metastasis and subsequent prognosis

Authors: Jai Grewal, Santosh Kesari

Published in: Breast Cancer Research | Issue 2/2008

Login to get access

Abstract

Determining the status of breast cancer surface receptors (estrogen receptor, progesterone receptor, HER2/neu) has become routine in the care of patients with this disease and has proven to be helpful in guiding treatment. For this reason, breast cancer has become a model for molecularly guided therapy in solid tumors. Emerging data support that these receptors are associated with risk for developing brain metastases. Additionally, once brain metastases have occurred these receptors may also correlate with prognosis.
Literature
1.
Nam B-H, Kim SY, Han HS, Kwon Y, Lee KS, Kim TH, Ro J: Breast cancer subtypes and survival in patients with brain metastases. Breast Cancer Res. 2008, 10: R20-10.1186/bcr1870.CrossRefPubMedPubMedCentral
2.
Hicks DG, Short SM, Prescott NL, Tarr SM, Coleman KA, Yoder BJ, Crowe JP, Choueiri TK, Dawson AE, Budd GT, Tubbs RR, Casey G, Weil RJ: Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR. Am J Surg Pathol. 2006, 30: 1097-1104.CrossRefPubMed
3.
Miller KD, Weathers T, Haney LG, Timmerman R, Dickler M, Shen J, Sledge GW: Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. Ann Oncol. 2003, 14: 1072-1077. 10.1093/annonc/mdg300.CrossRefPubMed
4.
Tham YL, Sexton K, Kramer R, Hilsenbeck S, Elledge R: Primary breast cancer phenotypes associated with propensity for central nervous system metastases. Cancer. 2006, 107: 696-704. 10.1002/cncr.22041.CrossRefPubMed
5.
Weitzen R, Zach L, Kaufman B, Tichler T, Rath P, Pfeffer R: High incidence of brain metastasis (BM) in patients on trastuzumab (H) for advanced breast cancer [abstract]. Proc Am Soc Clin Oncol. 2002, 21: 1936-
6.
Carey LA, Dees EC, Sawyer L, Gatti L, Moore DT, Collichio F, Ollila DW, Sartor CI, Graham ML, Perou CM: The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res. 2007, 13: 2329-2334. 10.1158/1078-0432.CCR-06-1109.CrossRefPubMed
7.
Liedtke C, Mazouni C, Hess KR, André F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, Cristofanilli M, Hortobagyi GN, Pusztai L: Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol. 2008
8.
Pestalozzi BC, Brignoli S: Trastuzumab in CSF. J Clin Oncol. 2000, 18: 2349-2351.PubMed
9.
Stemmler HJ, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V: Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs. 2007, 18: 23-28. 10.1097/01.cad.0000236313.50833.ee.CrossRefPubMed
10.
Baculi RH, Suki S, Nisbett J, Leeds N, Groves M: Meningeal carcinomatosis from breast carcinoma responsive to trastuzumab. J Clin Oncol. 2001, 19: 3297-3298.PubMed
11.
Fuchs IB, Loebbecke M, Buhler H, Stoltenburg-Didinger G, Heine B, Lichtenegger W, Schaller G: HER2 in brain metastases: issues of concordance, survival, and treatment. J Clin Oncol. 2002, 20: 4130-4133. 10.1200/JCO.2002.04.016.CrossRefPubMed
12.
Grewal J, Groves MD, Bekele BN, Yung WA: The role of HER2/neu, estrogen, and progesterone receptor status in the risk and survival of breast cancer leptomeningeal metastasis (2007 ASCO Annual Meeting Proceedings Part I) [abstract]. J Clin Oncol. 2007, 25: 11512-
Metadata
Title
Breast cancer surface receptors predict risk for developing brain metastasis and subsequent prognosis
Authors
Jai Grewal
Santosh Kesari
Publication date
01-04-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 2/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1868

Other articles of this Issue 2/2008

Breast Cancer Research 2/2008 Go to the issue

Research article

Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1gene

Research article

Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer

Research article

Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study

Viewpoint

Breast cancer metastasis: a microRNA story

Letter

Incorporating tumor immunohistochemical markers in BRCA1 and BRCA2 carrier prediction

Research article

TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits