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Breast Cancer Research
Published in: Breast Cancer Research 1/2008

01-02-2008 | Viewpoint

The role of single nucleotide polymorphisms in breast cancer metastasis

Authors: James M Rae, Todd C Skaar, Susan G Hilsenbeck, Steffi Oesterreich

Published in: Breast Cancer Research | Special Issue 1/2008

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Abstract

Our understanding of many aspects of cancer biology has been advanced through the use of modern genetics. These studies have already shown that germ line polymorphisms play a significant role in disease initiation and response to therapy. However, what is less well studied is the role of germ line polymorphisms in cancer progression. Studies in rodents indicate that differential susceptibility to cancer metastasis can be heritable; thus, the search for the genes that control cancer metastasis is underway. Although some provocative studies suggest potential candidates for metastasis regulating genes, the conclusive identification of a specific inherited genetic variant that alters metastatic potential awaits further studies.
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Metadata
Title
The role of single nucleotide polymorphisms in breast cancer metastasis
Authors
James M Rae
Todd C Skaar
Susan G Hilsenbeck
Steffi Oesterreich
Publication date
01-02-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 1/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1842

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