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Breast Cancer Research
Published in: Breast Cancer Research 4/2006

01-08-2006 | Commentary

Snail in the frame of malignant tumor recurrence

Authors: Bram De Craene, Geert Berx

Published in: Breast Cancer Research | Issue 4/2006

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Abstract

Snail plays an important role in the epithelial-to-mesenchymal transition during development and in tumor progression. Induction of Snail expression coincides with drastic morphological changes in cultured epithelial cells. Recently, a new role for Snail in tumor recurrence has been inferred from a reversible HER-2/neu-induced breast cancer mouse model. Comparative transcriptome analysis of human primary breast cancers suggests that elevated Snail expression is correlated with decreased relapse-free survival. Further characterization of Snail as master regulator in this process might enhance our understanding of the molecular and cellular changes during and after breast tumor recurrence.
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Metadata
Title
Snail in the frame of malignant tumor recurrence
Authors
Bram De Craene
Geert Berx
Publication date
01-08-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1521

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