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Breast Cancer Research
Published in: Breast Cancer Research 1/2005

01-05-2005 | Oral presentation

Adjuvant chemotherapy for operable breast cancer: old vs new schema

Authors: P Valagussa, L Gianni, G Bonadonna

Published in: Breast Cancer Research | Special Issue 1/2005

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Excerpt

In 1975 we presented our first report on the efficacy of cyclophosphamide, methotrexate and fluorouracil (CMF) as adjuvant treatment for node-positive breast cancer. Thirty years later, the results of this study demonstrate that the significant advantage in both relapse-free (reduction in relative risk for relapse of 29%) and overall survival (reduction in relative risk for death of 21%) persists over the years and that adjuvant CMF can exert a moderate but worthwhile suppression of micrometastases, regardless of anatomical sites [1]. …
Literature
1.
Bonadonna G, Molterni A, Zambetti M, Daidone MG, Pilotti S, Gianni L, Valagussa P: 30 years' follow up of randomized studies of adjuvant CMF in operable breast cancer: cohort study. BMJ. 2005, 330: 217-220. 10.1136/bmj.38314.622095.8F.CrossRefPubMedPubMedCentral
2.
Early Breast Cancer Trialists' Collaborative Group.: Polychemotherapy for rearly breast cancer. Lancet. 1998, 352: 930-942. 10.1016/S0140-6736(98)03301-7.CrossRef
3.
Bonadonna G, Zambetti M, Gianni L, Valagussa P: Clinical relevance of different sequencing of doxorubicin and cyclophosphamide, methotrexate, and fluorouracil operable breast cancer. J Clin Oncol . 2004, 22: 1614-1620. 10.1200/JCO.2004.07.190.CrossRefPubMed
4.
Fisher B: The evolution of paradigms for the management of breast cancer: a personal perspective. Cancer Res. 1992, 52: 2371-2383.PubMed
Metadata
Title
Adjuvant chemotherapy for operable breast cancer: old vs new schema
Authors
P Valagussa
L Gianni
G Bonadonna
Publication date
01-05-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 1/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1225

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