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Breast Cancer Research
Published in: Breast Cancer Research 2/2005

01-06-2005 | Poster Presentation

Discovering genetic profiles by array-CGH in familial breast tumors

Authors: PM Nederlof, E van Beers, S Joosse, FBL Hogervorst, LFA Wessels, P Devilee, C Cornelisse, R Oldenburg, S Verhoef, LJ van 't Veer

Published in: Breast Cancer Research | Special Issue 2/2005

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Excerpt

We have recently shown that BRCA1 breast tumors can be identified on the basis of their somatic genetic aberrations detected by comparative genomic hybridization (CGH) profiles with high performance (sensitivity: 96%) [1]. Also, BRCA2 show some specific alterations, but are more similar to sporadic breast tumors [2]. These results illustrate that breast tumors from different genetic backgrounds (BRCA1 and BRCA2) develop different genomic instabilities, and therefore genomic profiles. We hypothesize that this may also be true for BRCAx (BRCA3, BRCA 4, etc.) tumors. We therefore applied CGH to familial breast cancer cases from families without BRCA1/2 mutations. …
Literature
1.
Wessels LF, et al: Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors. Cancer Res. 2002, 62: 7110-7117.PubMed
2.
van Beers EH, et al: CGH profiles in human BRCA1 and BRCA2 breast tumors highlight differential sets of genomic aberrations. Cancer Res. 2005, 65: 822-827.PubMed
3.
Jong K, et al: Breakpoint identification and smoothing of array comparative genomic hybridization data. Bioinformatics. 2004, 20: 3636-3637.CrossRefPubMed
4.
Chung YJ, et al: A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. Genome Res. 2004, 14: 188-196. 10.1101/gr.1878804.CrossRefPubMedPubMedCentral
Metadata
Title
Discovering genetic profiles by array-CGH in familial breast tumors
Authors
PM Nederlof
E van Beers
S Joosse
FBL Hogervorst
LFA Wessels
P Devilee
C Cornelisse
R Oldenburg
S Verhoef
LJ van 't Veer
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1166

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