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Breast Cancer Research
Published in: Breast Cancer Research 2/2005

01-06-2005 | Poster Presentation

Identification of differentially expressed genes in canine mammary tumor cell lines using a newly developed canine-specific cDNA microarray

Authors: NAS Rao, R van den Ham, M van Wolferen, JA Mol

Published in: Breast Cancer Research | Special Issue 2/2005

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Excerpt

Tumors of the mammary gland belong to the most common tumors in the female dog. Ovarian hormones and signaling cascades involving them play an important role in mammary tumor formation and progression in the female dog, as early ovariectomy may reduce the incidence of mammary carcinoma from 30% to less than 2%. The phenotypic expression of canine mammary tumors may vary, even within one affected animal. In the past, growth factor-independent canine mammary cell lines have been isolated [1]. Molecular characterization of these cell lines and correlation of their molecular signatures to biological behavior may lead to better understanding of signaling pathways involved in mammary cancer and classification of spontaneous mammary tumors. …
Literature
1.
Hellmen E, Moller M, Blankenstein MA, Andersson L, Westermark B: Expression of different phenotypes in cell lines from canine mammary spindle-cell tumors and osteosarcomas indicating a pluripotent mammary stem cell origin. Breast Cancer Res Treat. 2000, 61: 197-210. 10.1023/A:1006410020384.CrossRefPubMed
2.
Roepman P, Wessels LF, Kettelarij N, Kemmeren P, Miles AJ, Lijn-zaad P, Tilanus MG, Koole R, Hordijk GJ, van der Vliet PC, et al: An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet. 2005, 37: 182-186. 10.1038/ng1502.CrossRefPubMed
3.
Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001, 98: 5116-5121. 10.1073/pnas.091062498.CrossRefPubMedPubMedCentral
Metadata
Title
Identification of differentially expressed genes in canine mammary tumor cell lines using a newly developed canine-specific cDNA microarray
Authors
NAS Rao
R van den Ham
M van Wolferen
JA Mol
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1165

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