Published in:
01-06-2005 | Poster Presentation
Molecular characterization of breast cell lines: a tool for breast cancer studies
Authors:
E Charafe-Jauffret, C Ginestier, F Monville, J Adélaïde, P Finetti, F Bertucci, L Xerri, J Jacquemier, D Birnbaum
Published in:
Breast Cancer Research
|
Special Issue 2/2005
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Excerpt
Breast cancer is a complex, heterogeneous disease at the molecular level. Recent advances proposed a new molecular taxonomy of breast cancer that defines molecular subtypes such as luminal or basal-like cancers. Hopefully this may modify breast cancer management. A great part of our knowledge on breast carcinomas is based on studies of breast cancer cell lines (BCC). Although many data are available on BCC lines, less is actually known on their molecular characterization. We have determined the molecular subtype of 31 BCC using DNA microarrays and confirmed their phenotype by immunohistochemistry (IHC) on 'cell microarrays' (CMA). …
