Published in:
01-06-2005 | Poster Presentation
Altered signaling in anti-estrogen-resistant human breast cancer cells
Authors:
AE Lykkesfeldt, T Frogne, JS Jepsen, CK Fog, SS Larsen
Published in:
Breast Cancer Research
|
Special Issue 2/2005
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Excerpt
Breast cancer patients with advanced disease often benefit from endocrine therapy. However, many patients develop acquired resistance to treatment after a period of response. In the Department of Tumor Endocrinology we have established several human breast cancer cell lines with acquired anti-estrogen resistance through long-term treatment with different anti-estrogens. These cell lines have been used for our studies of the signaling pathways, which may be activated in cells with acquired anti-estrogen resistance. …