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Breast Cancer Research
Published in: Breast Cancer Research 2/2005

01-06-2005 | Poster Presentation

Identification of novel sequence alterations and the functional analysis of the BRCA1 promoter/5'-UTR in families from Upper Silesia, Poland

Authors: J Pamuła, M Krześniak, H Zientek, WP Pękala, M Rusin, E Grzybowska

Published in: Breast Cancer Research | Special Issue 2/2005

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Excerpt

The human BRCA1 gene is under transcriptional control of two alternative promoters, α and β, that drive the transcription of exon 1a or exon 1b, respectively. Additionally, the 5'-UTR region, encompassing both exons 1, contains multiple putative and functional regulatory sequences. At the RNA level each exon 1 is linked, by splicing, with exon 2 that contains the translation start site. The aim of this study was to search for sequence alterations within the BRCA1 promoter and 5'-UTR in patients with breast and/or ovarian cancer, and to assess whether these sequence variants influence activity of the BRCA1 promoter region. …
Metadata
Title
Identification of novel sequence alterations and the functional analysis of the BRCA1 promoter/5'-UTR in families from Upper Silesia, Poland
Authors
J Pamuła
M Krześniak
H Zientek
WP Pękala
M Rusin
E Grzybowska
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1090

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