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Breast Cancer Research
Published in: Breast Cancer Research 1/2000

01-12-2001 | Paper Report

Iressa inhibits growth of HER-2-overexpressing cells

Author: Fatima Cardoso

Published in: Breast Cancer Research | Issue 1/2000

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Excerpt

ZD1839 or Iressa is a quinazoline tyrosine kinase inhibitor selective for the epidermal growth factor receptor (EGFR). Due to its oral bioavailability and antitumor activity against a broad range of mouse xenograft models, it was selected for clinical development and has now reached phase II-III clinical trials. Although it selectively inhibits EGFR, the molecular bases for the sensitivity to this compound are not fully understood. EGFR overexpression alone does not seem to be neither sufficient nor indispensable for tumor sensitivity to Iressa. …
Literature
1.
Moasser MM, Basso A, Averbuch SD, Rosen N: The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001, 61: 7184-7188.PubMed
Metadata
Title
Iressa inhibits growth of HER-2-overexpressing cells
Author
Fatima Cardoso
Publication date
01-12-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2001-72400

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