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Breast Cancer Research
Published in: Breast Cancer Research 1/2000

01-12-2000 | Paper Report

APCgene mutations in human breast cancers

Author: Chris Jones

Published in: Breast Cancer Research | Issue 1/2000

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Excerpt

The importance of APC gene mutations in the initiation step of both familial and sporadic colorectal carcinogenesis is well known. Somatic mutations of this gene have also been implicated in pancreatic, gastric and oesophageal cancers. In contrast, only a few APC mutations have been reported in primary human breast cancers. The vast majority of reported APC mutations are protein-truncating, and a novel yeast-based screening method for detection of truncating mutations is presented here. …
Literature
1.
Furuuchi K, Tada M, Yamada H, Kataoka A, Furuuchi N, Hamada J, Takahashi M, Todo S, Moriuchi T: Somatic mutations of the APCgene in primary breast cancers. Am J Pathol. 2000, 156: 1997-2005. CrossRefPubMedPubMedCentral
Metadata
Title
APCgene mutations in human breast cancers
Author
Chris Jones
Publication date
01-12-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2000-66710

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