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Alzheimer's Research & Therapy
Published in: Alzheimer's Research & Therapy 1/2014

01-02-2014 | Review

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

Authors: Haakon B Nygaard, Christopher H van Dyck, Stephen M Strittmatter

Published in: Alzheimer's Research & Therapy | Issue 1/2014

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Abstract

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, afflicting more than one-third of people over the age of 85. While many therapies for AD are in late-stage clinical testing, rational drug design based on distinct signaling pathways in this disorder is only now emerging. Here we review the putative signaling pathway of amyloid-beta (Aβ), by which the tyrosine kinase Fyn is activated via cell surface binding of Aβ oligomers to cellular prion protein. Several lines of evidence implicate Fyn in the pathogenesis of AD, and its interaction with both Aβ and Tau renders Fyn a unique therapeutic target that addresses both of the major pathologic hallmarks of AD. We are currently enrolling patients in a phase Ib study of saracatinib (AZD0530), a small molecule inhibitor with high potency for Src and Fyn, for the treatment of AD. The results of this trial and a planned phase IIa multisite study will provide important data regarding the potential for this therapeutic strategy in AD.
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Metadata
Title
Fyn kinase inhibition as a novel therapy for Alzheimer’s disease
Authors
Haakon B Nygaard
Christopher H van Dyck
Stephen M Strittmatter
Publication date
01-02-2014
Publisher
BioMed Central
Published in
Alzheimer's Research & Therapy / Issue 1/2014
Electronic ISSN: 1758-9193
DOI
https://doi.org/10.1186/alzrt238

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