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Alzheimer's Research & Therapy
Published in: Alzheimer's Research & Therapy 1/2013

Open Access 01-02-2013 | Research

18F-florbetaben Aβ imaging in mild cognitive impairment

Authors: Kevin Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Gaël Chételat, Parnesh Raniga, Rachel S Mulligan, Olivier Salvado, Barbara Putz, Katrin Roth, Colin L Masters, Cornelia B Reininger, Christopher C Rowe

Published in: Alzheimer's Research & Therapy | Issue 1/2013

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Abstract

Introduction

18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).

Methods

Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.

Results

High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden.

Conclusion

Higher Aβ deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
Appendix
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Metadata
Title
18F-florbetaben Aβ imaging in mild cognitive impairment
Authors
Kevin Ong
Victor L Villemagne
Alex Bahar-Fuchs
Fiona Lamb
Gaël Chételat
Parnesh Raniga
Rachel S Mulligan
Olivier Salvado
Barbara Putz
Katrin Roth
Colin L Masters
Cornelia B Reininger
Christopher C Rowe
Publication date
01-02-2013
Publisher
BioMed Central
Published in
Alzheimer's Research & Therapy / Issue 1/2013
Electronic ISSN: 1758-9193
DOI
https://doi.org/10.1186/alzrt158

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