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EJNMMI Research
Published in: EJNMMI Research 1/2013

Open Access 01-12-2013 | Original research

Imaging of the appearance time of cerebral blood using [15O]H2O PET for the computation of correct CBF

Authors: Nobuyuki Kudomi, Yukito Maeda, Yasuhiro Sasakawa, Toshihide Monden, Yuka Yamamoto, Nobuyuki Kawai, Hidehiro Iida, Yoshihiro Nishiyama

Published in: EJNMMI Research | Issue 1/2013

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Abstract

Background

Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H2 15O (or C15O2) can quantify CBF and apply kinetic analyses, including autoradiography (ARG) and the basis function methods (BFM). These approaches, however, are sensitive to input function errors such as the appearance time of cerebral blood (ATB), known as the delay time. We estimated brain ATB in an image-based fashion to correct CBF by accounting for differences in computed CBF values using three different analyses: ARG and BFM with and without fixing the partition coefficient.

Methods

Subject groups included those with no significant disorders, those with elevated cerebral blood volume, and those with reduced CBF. All subjects underwent PET examination, and CBF was estimated using the three analyses. The ATB was then computed from the differences of the obtained CBF values, and ATB-corrected CBF values were computed. ATB was also estimated for regions of interest (ROIs) of multiple cortical regions. The feasibility of the present method was tested in a simulation study.

Results

There were no significant differences in the obtained ATB between the image- and ROI-based methods. Significantly later appearance was found in the cerebellum compared to other brain regions for all groups. In cortical regions where CBF was reduced due to occlusive lesions, the ATB was 0.2 ± 1.2 s, which was significantly delayed relative to the contralateral regions. A simulation study showed that the ATB-corrected CBF was less sensitive to errors in input function, and noise on the tissue curve did not enhance the degree of noise on ATB-corrected CBF image.

Conclusions

This study demonstrates the potential utility of visualizing the ATB in the brain, enabling the determination of CBF with less sensitivity to error in input function.
Appendix
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Metadata
Title
Imaging of the appearance time of cerebral blood using [15O]H2O PET for the computation of correct CBF
Authors
Nobuyuki Kudomi
Yukito Maeda
Yasuhiro Sasakawa
Toshihide Monden
Yuka Yamamoto
Nobuyuki Kawai
Hidehiro Iida
Yoshihiro Nishiyama
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2013
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/2191-219X-3-41

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