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Experimental Hematology & Oncology
Published in: Experimental Hematology & Oncology 1/2014

Open Access 01-12-2014 | Review

Childhood B-acute lymphoblastic leukemia: a genetic update

Authors: Jennifer S Woo, Michael O Alberti, Carlos A Tirado

Published in: Experimental Hematology & Oncology | Issue 1/2014

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Abstract

In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cytogenetics utilizing array-based technologies and next-generation sequencing (NGS) techniques have revealed exciting insights into the genetic basis of this disease, with the hopes of developing individualized treatment plans for affected children. In this comprehensive review, we discuss our current understanding of childhood (pediatric) B-ALL and highlight the most recent genetic advances and their therapeutic implications.
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Metadata
Title
Childhood B-acute lymphoblastic leukemia: a genetic update
Authors
Jennifer S Woo
Michael O Alberti
Carlos A Tirado
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2014
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/2162-3619-3-16

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