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Open Access 01-12-2012 | Case report

Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation

Authors: Paul Farnsworth, David Ward, Vijay Reddy

Published in: Experimental Hematology & Oncology | Issue 1/2012

Abstract

We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previously published studies, this is the first report where a patient did not receive additional chemotherapy after relapse, nor did she receive donor lymphocyte infusions. With nilotinib, the patient reverted back to normal blood counts and 100% donor reconstitution by single tandem repeat (STR) chimerism analysis in the bone marrow and in peripheral blood, granulocytes, T and B-lymphocytes. This report also highlights the use of nilotinib in combination with extracorporeal photopheresis (ECP) for concomitant graft-versus-host disease. Our data suggests that ECP, together with nilotinib, did not adversely affect the overall Graft-versus-leukemia (GVL) effect.

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Title: Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation
Authors: Paul Farnsworth
David Ward
Vijay Reddy
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Experimental Hematology & Oncology / Issue 1/2012
Electronic ISSN: 2162-3619
DOI: https://doi.org/10.1186/2162-3619-1-29

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