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Translational Neurodegeneration
Published in: Translational Neurodegeneration 1/2012

Open Access 01-12-2012 | Review

Advance in the pathogenesis and treatment of Wilson disease

Authors: Qin-Yun Dong, Zhi-Ying Wu

Published in: Translational Neurodegeneration | Issue 1/2012

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Abstract

Wilson disease is an autosomal recessive disorder of copper metabolism. Diagnosis depends primarily on clinical features, biochemical parameters and the presence of the Kayser-Fleischer ring. Genetic analysis for mutations within ATP7B is a convincing diagnostic tool. The traditional treatment for WD includes chelation of excessive copper accumulation and reduction of copper intake. Medical therapy is effective but WD is not yet curable. Liver transplantation is especially helpful for patients who fail to respond to medical therapy or present with fulminant liver failure, although evaluation of its long-term effect are still in need.
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Metadata
Title
Advance in the pathogenesis and treatment of Wilson disease
Authors
Qin-Yun Dong
Zhi-Ying Wu
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Translational Neurodegeneration / Issue 1/2012
Electronic ISSN: 2047-9158
DOI
https://doi.org/10.1186/2047-9158-1-23

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