Published in:
Open Access
01-12-2014 | Meeting abstract
Bile acid-induced modulation of virus replication
Authors:
Anna-Kathrin Schupp, Dirk Graf
Published in:
European Journal of Medical Research
|
Special Issue 1/2014
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Excerpt
Bile acids function as signaling molecules. As such they are involved in cellular immunological processes mainly mediating anti-inflammatory effects. They suppress cell-mediated innate and adaptive immunity through different signaling pathways, e.g. mediated by the nuclear bile acid receptor farnesoid x receptor (FXR) or the G-coupled receptor TGR5 at the outer plasma membrane. In the past it became increasingly evident that bile acids also modulate viral replication, which is reviewed herein. …