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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2014

Open Access 01-12-2014 | Meeting abstract

Immune functions during chronic viral infections

Authors: Philipp Lang, Dieter Häussinger, Karl S Lang

Published in: European Journal of Medical Research | Special Issue 1/2014

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Excerpt

Chronic viral infections display a major health burden worldwide. Immune control of chronic viral infections requires a balanced interplay between immune activation promoting virus clearance and deactivation of anti-viral immunity to prevent tissue damage. Our research is focused on identifying mechanisms regulating the balanced immune control of viral infections. …
Literature
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Lang PA, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C, Meryk A, Kulawik A, Cervantes-Barragan L, Van Rooijen N, Kalinke U, Ludewig B, Hengartner H, Harris N, Häussinger D, Ohashi PS, Zinkernagel RM, Lang KS: Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology 2010, 52: 25–32.PubMedCrossRef
2.
Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS: Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A 2012, 109: 1210–1215. 10.1073/pnas.1118834109PubMedCentralPubMedCrossRef
3.
Lang PA, Contaldo C, Georgiev P, El-Badry AM, Recher M, Kurrer M, Cervantes-Barragan L, Ludewig B, Calzascia T, Bolinger B, Merkler D, Odermatt B, Bader M, Graf R, Clavien PA, Hegazy AN, Lohning M, Harris NL, Ohashi PS, Hengartner H, Zinkernagel RM, Lang KS: Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 2008, 14: 756–761. 10.1038/nm1780PubMedCrossRef
4.
Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Kumar Maney S, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang KS: Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Cell Death Differ 2013, 20: 649–658. 10.1038/cdd.2012.167PubMedCentralPubMedCrossRef
Metadata
Title
Immune functions during chronic viral infections
Authors
Philipp Lang
Dieter Häussinger
Karl S Lang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue Special Issue 1/2014
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-19-S1-S25

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