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European Journal of Medical Research

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Open Access 01-12-2013 | Research

RETRACTED ARTICLE: Screening of key genes in gastric cancer with DNA microarray analysis

Authors: Yong Jin, Wei Da

Published in: European Journal of Medical Research | Issue 1/2013

Abstract

Background

The aim of this study was to identify key genes and novel potential therapeutic targets related to gastric cancer (GC) by comparing cancer tissue samples and healthy control samples using DNA microarray analysis.

Methods

Microarray data set GSE19804 was downloaded from Gene Expression Omnibus. Preprocessing and differential analysis were conducted with of R statistical software packages, and a number of differentially expressed genes (DEGs) were obtained. Cluster analysis was also done with gene expression values. Functional enrichment analysis was performed for all the DEGs with DAVID tools. The significantly up- and downregulated genes were selected out and their interactors were retrieved with STRING and HitPredict, followed by construction of networks. For all the genes in the two networks, GeneCodis was chosen for gene function annotation.

Results

A total of 638 DEGs were identified, and we found that SPP1 and FABP4 were the markedly up- and downregulated genes, respectively. Cell cycle and regulation of proliferation were the most significantly overrepresented functional terms in up- and downregulated genes. In addition, extracellular matrix–receptor interaction was found to be significant in the SPP1-included interaction network.

Conclusions

A range of DEGs were obtained for GC. These genes not only provided insights into the pathogenesis of GC but also could develop into biomarkers for diagnosis or treatment.

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Title: RETRACTED ARTICLE: Screening of key genes in gastric cancer with DNA microarray analysis
Authors: Yong Jin
Wei Da
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2013
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-18-37

At a glance: The STEP trials

Springer Medicine

RETRACTED ARTICLE: Screening of key genes in gastric cancer with DNA microarray analysis

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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