Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Journal of Medical Research
Published in: European Journal of Medical Research 9/2011

01-12-2011 | Case report

Successful Non-Invasive treatment of stricturing fibrosing colonopathy in an adult patient

Authors: G Terheggen, D Dieninghoff, E Rietschel, U Drebber, W Kruis, L Leifeld

Published in: European Journal of Medical Research | Issue 9/2011

Login to get access

Abstract

Objective

Fibrosing colonopathy (FC) is a rare entity associated with cystic fibrosis (CF). Until now, patients with stricturing FC have usually been treated surgically. In this instance, we aimed at avoiding surgery by applying a new conservative approach.

Methods

Case report on an adult with CF who developed persistent abdominal pain due to a non-passable stricture in the right transverse colon. Histology confirmed fibrosing colonopathy.

Results

Initially we treated the patient with prednisolone pulse therapy and additive antibiotic therapy. For maintenance therapy we administered budesonide. The patient underwent clinical, laboratory and endoscopic follow-up over a three-year period. The stricture healed and was easy to pass. A relapse in the cecum at the ileocecal valve again improved under steroid and antibiotic therapy.

Conclusions

We present a novel therapeutic approach for advanced stricturing FC in an adult patient which successfully avoided surgery (right hemicolectomy) over a three year follow up.
Literature
1.
The Cystic Fibrosis Genotype-Phenotype Consortium. Correlation between genotype and phenotype in patients with cystic fibrosis N Engl J Med 1993, 329: 1308–13.
2.
FitzSimmons SC, Burkhart GA, Borowitz D, et al.: Highdose pancreatic enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N Engl J Med 1997, 336: 1283–9. 10.1056/NEJM199705013361803PubMedCrossRef
3.
Häusler M, Meilicke R, Biesterfeld S, Heimann G: First adult patient with fibrosing colonopathy. Am J Gastroenterol 1998, 93: 1171–2.PubMedCrossRef
4.
Mack EH, Brett AS, Brown D: Fibrosing colonopathy in an adult cystic fibrosis patient after discontinuing pancreatic enzyme therapy. South Med J 2004, 97: 901–4. 10.1097/01.SMJ.0000129939.14179.FEPubMedCrossRef
5.
Franzen D, Went P, Buhlmann U: Fibrosing colonopathy in absence of pancreatic enzyme supplementation in one adult patient with cystic fibrosis. Indian J Gastroenterol 2008, 27: 133–4.PubMed
6.
Bansi DS, Price A, Russell C, Sarner M: Fibrosing colonopathy in an adult owing to over use of pancreatic enzyme supplements. Gut 2000, 46: 283–5. 10.1136/gut.46.2.283PubMedCentralPubMedCrossRef
7.
Gaia E, Sambatoro A, De Giuli P, Angeli A: Adult fibrosing colonopathy associated with mesalazine treatment. Am J Gastroenterol 2001, 96: 2508–9.PubMedCrossRef
8.
Haber HP, Benda N, Fitzke G, et al.: Colonic wall thickness measured by ultrasound: striking differences in patients with cystic fibrosis versus healthy controls. Gut 1997, 40: 406–11.PubMedCentralPubMedCrossRef
9.
Dialer I, Hundt C, Bertele-Harms RM, Harms HK: Sonographic evaluation of bowel wall thickness in patients with cystic fibrosis. J Clin Gastroenterol 2003, 37: 55–60. 10.1097/00004836-200307000-00014PubMedCrossRef
10.
Reichard KW, Vinocur CD, Franco M, et al.: Fibrosing colonopathy in children with cystic fibrosis. J Pediatr Surg 1997, 32: 237–41. 10.1016/S0022-3468(97)90186-XPubMedCrossRef
11.
Schwarzenberg SJ, Wielinski CL, Shamieh I, et al.: Cystic fibrosis-associated colitis and fibrosing colonopathy. J Pediatr 1995, 127: 565–70. 10.1016/S0022-3476(95)70113-3PubMedCrossRef
12.
Dodge JA: The aetiology of fibrosing colonopathy. Postgrad Med J 1996,72(suppl 2):S52–5.PubMed
13.
Lloyd-Still JD, Beno DW, Kimura RM: Cystic fibrosis colonopathy. Curr Gastroenterol Rep 1999, 1: 231–7. 10.1007/s11894-999-0040-4PubMedCrossRef
14.
Lloyd-Still JD: Cystic fibrosis and colonic strictures. A new "iatrogenic" disease. J Clin Gastroenterol 1995, 21: 2–5. 10.1097/00004836-199507000-00001PubMedCrossRef
15.
Stevens JC, Maguiness KM, Hollingsworth J, et al.: Pancreatic enzyme supplementation in cystic fibrosis patients before and after fibrosing colonopathy. J Pediatr Gastroenterol Nutr 1998, 26: 80–4. 10.1097/00005176-199801000-00014PubMedCrossRef
Metadata
Title
Successful Non-Invasive treatment of stricturing fibrosing colonopathy in an adult patient
Authors
G Terheggen
D Dieninghoff
E Rietschel
U Drebber
W Kruis
L Leifeld
Publication date
01-12-2011
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 9/2011
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-16-9-411

Other articles of this Issue 9/2011

European Journal of Medical Research 9/2011 Go to the issue

Case report

Penicillium marneffei infection presenting as vulv-ulcer in an HIV-infected woman

Research

Investigation of the flexibility of bronchoscopes

Research

Depression and religiosity in older age

Research

TB or not TB? Difficulties in the diagnosis of tuberculosis in HIV-negative immigrants to Germany

Research

Increased levels of anti-glycan antibodies in patients with cystic fibrosis

Research

Improvement of quality of life in patients with concomitant allergic asthma and atopic dermatitis: one year follow-up of omalizumab therapy