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European Journal of Medical Research
Published in: European Journal of Medical Research 4/2011

01-12-2011 | Review

Pharmacology and metabolism of voriconazole and posaconazole in the treatment of invasive aspergillosis-review of the literature

Authors: M Sandherr, G Maschmeyer

Published in: European Journal of Medical Research | Issue 4/2011

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Abstract

Invasive fungal infections, predominantly aspergillosis and candidiasis, are among the most important causes of morbidity and mortality in immunocompromised patients. Primarily, patients with acute leukemia undergoing myelosuppressive chemotherapy and allogeneic stem cell transplant recipients are affected. Up to 60% of patients with invasive aspergillosis, the most common invasive mycosis among patients with hematologic malignancies, may still die of their infection, once it has become clinically overt. The spectrum of antifungal agents for clinical use now has expanded over the past ten years and includes the novel class of the echinocandins and two newer generation triazoles with an extended spectrum of activity against a wide range of fungal pathogens. This review will address pharmacological characteristics of the two broad-spectrum antifungal azoles, voriconazole and Posaconazole, which are important for their proper use in clinical practice.
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Metadata
Title
Pharmacology and metabolism of voriconazole and posaconazole in the treatment of invasive aspergillosis-review of the literature
Authors
M Sandherr
G Maschmeyer
Publication date
01-12-2011
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 4/2011
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-16-4-139

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