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European Journal of Medical Research

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01-12-2010 | Research

Tumor markers as a diagnostic key for hilar cholangiocarcinoma

Authors: B Juntermanns, S Radunz, M Heuer, S Hertel, H Reis, JP Neuhaus, S Vernadakis, T Trarbach, A Paul, GM Kaiser

Published in: European Journal of Medical Research | Issue 8/2010

Abstract

Objective

Hilar cholangiocarcinoma is the fourth most common gastrointestinal malignancy. CA19-9 and CEA are helpful devices in the management of gastrointestinal malignancies and belong to clinical routine in surgical oncology. But the validity of these parameters in terms of tumor extension and prognosis of bile duct malignancies still remains unclear.

Methods

From 1998 to 2008, we obtained preoperative CA19-9 and CEA serum levels in 136 patients with hilar cholangiocarcinoma. We correlated tumor stage, resectability rate and survival with preoperative CA 19-9 and CEA serum levels.

Results

CA19-9 (UICC I: 253 ± 561 U/ml; UICC II: 742 ± 1572 U/ml; UICC III: 906 ± 1708 U/ml; UICC IV: 1707 ± 3053 U/ml) and CEA levels (UICC I: 2.9 ± 3.8 U/ml; UICC II: 4.6 ± 6.5 U/ml; UICC III: 18.1 ± 29.6 U/ml; UICC IV: 22.7 ± 53.9 U/ml) increase significantly with rising tumor stage. Patients with pre operative serum levels of CA19-9 (> 1000 U/ml) and CEA (> 14.4 ng/ml) showed a significant poorer resectability rate and survival than patients with lower CA19-9 and CEA serum levels respectively.

Conclusion

CA19-9 and CEA serum levels are associated with the tumor stage. If preoperatively obtained CA19-9 and CEA serum levels are highly elevated patients have an even worse survival and the frequency of irresectability is significantly higher.

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Title: Tumor markers as a diagnostic key for hilar cholangiocarcinoma
Authors: B Juntermanns
S Radunz
M Heuer
S Hertel
H Reis
JP Neuhaus
S Vernadakis
T Trarbach
A Paul
GM Kaiser
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 8/2010
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-15-8-357

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tumor markers as a diagnostic key for hilar cholangiocarcinoma

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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