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European Journal of Medical Research
Published in: European Journal of Medical Research 10/2010

01-12-2010 | Research

Pulse wave velocity predicts mortality in renal transplant patients

Authors: A Mitchell, A Opazo Saez, M Kos, O Witzke, A Kribben, J Nürnberger

Published in: European Journal of Medical Research | Issue 10/2010

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Abstract

Background

Measuring arterial stiffness using pulse wave velocity (PWV) has become an important tool to assess vascular function and cardiovascular mortality. For subject with hypertension, end-stage renal disease and diabetes, PWV has been shown to predict cardiovascular and all-cause mortality. We hypothesize that PWV would also predict mortality in subjects who have undergone kidney transplantation.

Methods

A cohort of 330 patients with renal transplantation was studied with a mean age at entry 51.4 ± 0.75 years. Mean follow-up was 3.8 years (± 0.7 years); 16 deaths occurred during follow-up. At entry, together with standard clinical and biochemical parameters, PWV was determined from pressure tracing over carotid and femoral arteries.

Results

With increasing PWV, there was a significant increase in age, systolic blood pressure and pulse pressure. In addition, subjects with higher PWV also exhibited more frequently the presence of coronary heart disease. On the basis of Cox analyses, PWV and systolic blood pressure emerged as predictors of all-cause mortality.

Conclusion

These results provide evidence that PWV is a strong predictor of all-cause mortality in the population of renal transplant recipients.
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Metadata
Title
Pulse wave velocity predicts mortality in renal transplant patients
Authors
A Mitchell
A Opazo Saez
M Kos
O Witzke
A Kribben
J Nürnberger
Publication date
01-12-2010
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 10/2010
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-15-10-452

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