Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Journal of Medical Research
Published in: European Journal of Medical Research 6/2009

01-12-2009 | Review

Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature

Authors: E Bölke, H Krasniqi, G Lammering, R Engers, C Matuschek, S Gripp, PA Gerber, G Fischer, M Peiper, S Shaikh, W Budach, K Orth

Published in: European Journal of Medical Research | Issue 6/2009

Login to get access

Abstract

Desmoid tumors are fibroblastic/myofibroblastic neoplasms, which originate from musculo-aponeurotic structures and are classified as deep fibromatoses. Despite their benign histologic appearance and lack of metastatic potential, desmoid tumors may cause aggressive local infiltrations and compression of surrounding structures. They are often associated with female gender, familial adenomatous polyposis (FAP) and sporadically may occur at sites of previous trauma, scars or irradiation. Molecular studies have demonstrated that these patients are associated with a bi-allelic APC mutation in the affected tissue. Radical tumor resection with free margins remains the first therapy of choice. In cases with anatomical or technical limitations for a wide excision, radiation therapy represents a proven and effective alternative or supplementary treatment.
Literature
1.
Brueckl WM, Ballhausen WG, Förtsch T, Günther K, Fiedler W, Gentner B, et al.: Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors with a family history of colorectal carcinoma. Dis Colon Rectum 2005, 48: 1275–1281. 10.1007/s10350-004-0949-5PubMedCrossRef
2.
Sturt NJ, Gallagher MC, Bassett P, Philp CR, Neale KF, Tomlinson IP, et al.: Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation. Gut 2004, 53: 1832–1836. 10.1136/gut.2004.042705PubMedCentralPubMedCrossRef
3.
Raynham WH, Louw JH: Desmoid tumours in familial polyposis of the colon. S Afr J Surg 1971, 9: 133–140.PubMed
4.
Lopez R, Kemalyan N, Moseley HS, Dennis D, Vetto RM: Problems in diagnosis and management of desmoid tumors. Am J Surg 1990, 159: 450–453. 10.1016/S0002-9610(05)81243-7PubMedCrossRef
5.
Gaches C, Burke J: Desmoid tumour (fibroma of the abdominal wall) occurring in siblings. Br J Surg 1971, 58: 495–498. 10.1002/bjs.1800580706PubMedCrossRef
6.
Lee JC, Thomas JM, Phillips S, Fisher C, Moskovic E: Aggressive fibromatosis: MRI features with pathologic correlation. AJR Am J Roentgenol 2006, 186: 247–254. 10.2214/AJR.04.1674PubMedCrossRef
7.
Shields CJ, Winter DC, Kirwan WO, Redmond HP: Desmoid tumours. Eur J Surg Oncol 2001, 27: 701–706. 10.1053/ejso.2001.1169PubMedCrossRef
8.
Klemmer S, Pascoe L, DeCosse J: Occurrence of desmoids in patients with familial adenomatous polyposis of the colon. Am J Med Genet 1987, 28: 385–392. 10.1002/ajmg.1320280217PubMedCrossRef
9.
Caspari R, Olschwang S, Friedl W, Mandl M, Boisson C, Böker T, et al.: Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444. Hum Mol Genet 1995, 4: 337–340. 10.1093/hmg/4.3.337PubMedCrossRef
10.
Goy BW, Lee SP, Eilber F, Dorey F, Eckardt J, Fu YS, Juillard GJ, Selch MT: The role of adjuvant radiotherapy in the treatment of resectable desmoid tumors. Int J Radiat Oncol Biol Phys 1997, 39: 659–665. 10.1016/S0360-3016(97)00334-9PubMedCrossRef
11.
Bright-Thomas RM, Agrawal A, Hargest R: Preclinical studies of gene transfer for the treatment of desmoid disease in familial adenomatous polyposis. Br J Surg 2002, 89: 1563–1569. 10.1046/j.1365-2168.2002.02277.xPubMedCrossRef
12.
Micke O, Seegenschmiedt MH, German Cooperative group on Radiotherapy for Benign Diseases: Radiation Therapy for Aggressive Fibromatosis (Desmoid Tumors): Results of a National Pattern of Care Study. Int Rad Onc Biol Phys 2005, 61: 882–891. 10.1016/j.ijrobp.2004.07.705CrossRef
13.
Ballo MT, Zagars GK, Pollack A, et al.: Desmoid tumor: Prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol 1999, 17: 158–167.PubMed
14.
Nuyttens JJ, Rust PF, Thomas CR Jr, et al.: Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: A comparative review of 22 articles. Cancer 2000, 88: 1517–1523. 10.1002/(SICI)1097-0142(20000401)88:7<1517::AID-CNCR3>3.0.CO;2-9PubMedCrossRef
15.
Ballo MT, Zagars GK, Pollack A: Radiation therapy in the management of desmoid tumors. In J Radiat Oncol Phys 1998, 42: 1007–1014. 10.1016/S0360-3016(98)00285-5CrossRef
16.
Guadagnolo BA, Zagars GK, Ballo MT: Long-term outcomes for desmoid tumors treated with radiation therapy. Int J Rad Oncol Biol Phys 2008, 71: 441–447. 10.1016/j.ijrobp.2007.10.013CrossRef
17.
Abbas AE, Deschamps C, Cassivi SD, Nicols FC III, Allen MS, Schleck CD, Pairlero PC: Chest wall desmoid tumors: results of surgical intervention. Ann Thorac Surg 2004, 78: 1219–1223. 10.1016/j.athoracsur.2004.03.015PubMedCrossRef
18.
Meyerson SL, Dámico TA: Intrathoracic desmoid tumor: brief report and review of the literature. J Thorac Oncol 2008, 3: 656–659. 10.1097/JTO.0b013e3181757aa6PubMedCrossRef
19.
Allen PJ, Shriver CD: Desmoid tumors of the chest wall. Semin Thorac Cardiovasc Surg 1999, 11: 264–269.PubMedCrossRef
20.
Pairolero PC, Arnold PG: Chest wall tumors. Experience with 100 consecutive patients. J Thorac Cardiovasc Surg 1985, 90: 367–372.PubMed
21.
Kotiligam D, Lazar AJ, Pollock RE, Lev D: Desmoid tumor: a disease opportune for molecular insights. Histol Histopathol 2008,23(1):117–26. ReviewPubMed
Metadata
Title
Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature
Authors
E Bölke
H Krasniqi
G Lammering
R Engers
C Matuschek
S Gripp
PA Gerber
G Fischer
M Peiper
S Shaikh
W Budach
K Orth
Publication date
01-12-2009
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 6/2009
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-14-6-240

Other articles of this Issue 6/2009

European Journal of Medical Research 6/2009 Go to the issue

Research

Short-term outcome after posterior versus lateral surgical approach for total hip arthroplasty - a randomized clinical trial*

Case report

Dysplasia epiphysealis hemimelica of the distal ulna: a case report and review of the literature

Research

Natural history, clinical pattern, and surgical considerations of pneumatosis intestinalis

Research

Acoustic monitoring (RFM) of total hip arthroplasty results of a cadaver study

Research

BCL2-938C > A and CALCA-1786T > C polymorphisms in aseptic loosened total hip arthroplasty

Research

Impaired CD4-cell immune reconstitution upon HIV therapy in patients with toxoplasmic encephalitis compared to patients with pneumocystis pneumonia as AIDS indicating disease