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Clinical Sarcoma Research
Published in: Clinical Sarcoma Research 1/2013

Open Access 01-12-2013 | Research

Solitary fibrous tumors of the soft tissues: imaging features with histopathologic correlations

Authors: Zafaria G Papathanassiou, Marco Alberghini, Piero Picci, Eric Staals, Marco Gambarotti, Francesco Giuseppe Garaci, Daniel Vanel

Published in: Clinical Sarcoma Research | Issue 1/2013

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Abstract

Purpose

To describe the imaging features of soft tissue solitary fibrous tumors, with histopathological correlations and clinical outcome.

Material and methods

Twenty-seven patients with histologically proven SFTs were retrospectively evaluated. Imaging studies included six radiographs, five U/S studies, eighteen CT scans, fourteen MRI exams, and one angiography.

Results

On CT scans, two lesions were isodense and five were mildly hypodense compared to muscle while 11 lesions appeared heterogeneous-mixed of iso and hypodense areas. Heterogeneous enhancement was depicted in 13 lesions and four lesions enhanced homogeneously. Six lesions were partially calcified. On T1W MR images, seven lesions were isointense and one was slightly hyperintense relative to adjacent muscles while five lesions appeared heterogeneous-mixed of iso and hypointense areas. T2W images showed high SI in two cases and heterogeneous-mixed in seven cases. Enhancement was heterogeneous in six and homogeneous in four lesions. Patchy unenhanced areas (on CT and T1W MR images) along with patchy areas of low to markedly high SI on T2W images were depicted in 19 lesions. The enhanced portions correlated to areas of increased vascularity and cellularity. The four clinically more aggressive lesions could not be predicted on imaging.

Conclusion

Typical soft tissue SFTs are deep masses made of isodense and isointense areas relative to adjacent muscles mixed with hypodense and hypointense areas on unenhanced CT and MR T1W respectively. Variable enhancement patterns and mixed to high signal intensities on MRT2W are attributed to tumor’s cellularity, vascularity, collagen distribution and/or degeneration. Heterogeneity of SFTs affects imaging features on MRI and CT modalities. The biological behavior of soft tissue SFTs can not be predicted based solely either on histopathologic or imaging evaluation.
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Literature
1.
Regal MA, Al Rubaish AM, Al Ghoneimy YF, Hammad RI: Solitary benign fibrous tumors of the pleura. Asian Cardiovasc Thorac Ann. 2008, 16 (2): 139-142.CrossRefPubMed
2.
Klemperer P, Rabin CB: Primary neoplasms of the pleura: a report of five cases. Arch Pathol. 1931, 11: 385-411.
3.
Gengler C, Guillou L: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 2006, 48 (1): 63-74. 10.1111/j.1365-2559.2005.02290.xCrossRefPubMed
4.
Travis WD, Tazelaar H, Chung A: Mesenchymal tumours. World Health Organization classification of tumors: pathology and genetics of tumors of lung, pleura, thymus and heart. Edited by: Travis WD, Brambilla E, Muller-Hemerlick HK, Harris CC. 2004, P.142-P.143. Lyon: IARC Press,
5.
Briselli M, Mark EJ, Dickersin GR: Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer. 1981, 47 (11): 2678-2689. 10.1002/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO;2-9CrossRefPubMed
6.
Okike N, Bernatz PE, Woolner LB: Localized mesothelioma of the pleura: benign and malignant variants. J Thorac Cardiovasc Surg. 1978, 75 (3): 363-372.PubMed
7.
Cardillo G, Facciolo F, Cavazzana AO, Capece G, Gasparri R, Martelli M: Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients. Ann Thorac Surg. 2000, 70 (6): 1808-1812. 10.1016/S0003-4975(00)01908-1CrossRefPubMed
8.
Martin AJ, Fisher C, Igbaseimokumo U, Jarosz JM, Dean AF: Solitary fibrous tumours of the meninges: case series and literature review. J Neurooncol. 2001, 54 (1): 57-69. 10.1023/A:1012553119349CrossRefPubMed
9.
Kim HJ, Lee HK, Seo JJ, Kim HJ, Shin JH, Jeong AK, Lee JH, Cho KJ: MR imaging of solitary fibrous tumors in the head and neck. Korean J Radiol. 2005, 6 (3): 136-142. 10.3348/kjr.2005.6.3.136PubMedCentralCrossRefPubMed
10.
Jeong AK, Lee HK, Kim SY, Cho KJ: Solitary fibrous tumor of the parapharyngeal space: MR imaging findings. AJNR Am J Neuroradiol. 2002, 23 (3): 473-475.PubMed
11.
Chun HJ, Byun JY, Jung SE, Kim KH, Shinn KS: Benign solitary fibrous tumour of the pre-sacral space: MRI findings. Br J Radiol. 1998, 71 (846): 677-679.CrossRefPubMed
12.
Fuksbrumer MS, Klimstra D, Panicek DM: Solitary fibrous tumor of the liver: imaging findings. AJR Am J Roentgenol. 2000, 175 (6): 1683-1687. 10.2214/ajr.175.6.1751683CrossRefPubMed
13.
Moser T, Nogueira TS, Neuville A, Riehm S, Averous G, Weber JC, Veillon F: Delayed enhancement pattern in a localized fibrous tumor of the liver. AJR Am J Roentgenol. 2005, 184 (5): 1578-1580. 10.2214/ajr.184.5.01841578CrossRefPubMed
14.
Nagasako Y, Misawa K, Kohashi S, Sano H: Solitary fibrous tumor in the retroperitoneum. J Am Coll Surg. 2004, 198 (2): 322-323. 10.1016/j.jamcollsurg.2003.07.023CrossRefPubMed
15.
Kakihara D, Yoshimitsu K, Eto M, Matsuura S, Honda H: MRI of retroperitoneal solitary fibrous tumor in the suprarenal region. AJR Am J Roentgenol. 2007, 188 (6): W512-W514. 10.2214/AJR.05.0537CrossRefPubMed
16.
Wat SY, Sur M, Dhamanaskar K: Solitary fibrous tumor (SFT) of the pelvis. Clin Imaging. 2008, 32 (2): 152-156. 10.1016/j.clinimag.2007.07.003CrossRefPubMed
17.
Zhang WD, Chen JY, Cao Y, Liu QY, Luo RG: Computed tomography and magnetic resonance imaging findings of solitary fibrous tumors in the pelvis: correlation with histopathological findings. Eur J Radiol. 2009, [Epub ahead of print],
18.
O’Connell JX, Logan PM, Beauchamp CP: Solitary fibrous tumor of the periosteum. Hum Pathol. 1995, 26 (4): 460-462. 10.1016/0046-8177(95)90150-7CrossRefPubMed
19.
Suster S, Nascimento AG, Miettinen M, Sickel JZ, Moran CA: Solitary fibrous tumors of soft tissue. A clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol. 1995, 19 (11): 1257-1266. 10.1097/00000478-199511000-00005CrossRefPubMed
20.
Nielsen GP, O’Connell JX, Dickersin GR, Rosenberg AE: Solitary fibrous tumor of soft tissue: a report of 15 cases, including 5 malignant examples with light microscopic, immunohistochemical, and ultrastructural data. Mod Pathol. 1997, 10 (10): 1028-1037.PubMed
21.
Mentzel T, Bainbridge TC, Katenkamp D: Solitary fibrous tumour: clinicopathological, immunohistochemical, and ultrastructural analysis of 12 cases arising in soft tissues, nasal cavity and nasopharynx, urinary bladder and prostate. Virchows Arch. 1997, 430 (6): 445-453. 10.1007/s004280050054CrossRefPubMed
22.
Vallat-Decouvelaere AV, Dry SM, Fletcher CD: Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol. 1998, 22 (12): 1501-1511. 10.1097/00000478-199812000-00007CrossRefPubMed
23.
Abe S, Imamura T, Tateishi A, Park P, Nakano H, Harasawa A, Hashimoto H, Matsushita T: Intramuscular solitary fibrous tumor: a clinicopathological case study. J Comput Assist Tomogr. 1999, 23 (3): 458-462. 10.1097/00004728-199905000-00024CrossRefPubMed
24.
Hasegawa T, Matsuno Y, Shimoda T, Hasegawa F, Sano T, Hirohashi S: Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior. Hum Pathol. 1999, 30 (12): 1464-1473. 10.1016/S0046-8177(99)90169-7CrossRefPubMed
25.
Harrington P, Merchant WJ, Walsh ME: Solitary fibrous tumour of the forearm. A rare tumour in an atypical site. J Hand Surg Br. 1999, 24 (3): 370-372. 10.1054/jhsb.1998.0010CrossRefPubMed
26.
Krismann M, Adams H, Jaworska M, Müller KM, Johnen G: Benign solitary fibrous tumour of the thigh: morphological, chromosomal and differential diagnostic aspects. Langenbecks Arch Surg. 2000, 385 (8): 521-525. 10.1007/s004230000167CrossRefPubMed
27.
Riss O, Mamlouk O, Troufléau P, Depardieu C, Stinès J: [CT and MR imaging of a solitary fibrous tumor of the thigh]. J Radiol. 2000, 81 (11): 1643-1646.PubMed
28.
Akisue T, Matsumoto K, Kizaki T, Fujita I, Yamamoto T, Yoshiya S, Kurosaka M: Solitary fibrous tumor in the extremity: case report and review of the literature. Clin Orthop Relat Res. 2003, 411: 236-244.CrossRefPubMed
29.
Rakheja D, Wilson KS, Meehan JJ, Schultz RA, Maale GE, Timmons CF: Extrapleural benign solitary fibrous tumor in the shoulder of a 9-year-old girl: case report and review of the literature. Pediatr Dev Pathol. 2004, 7 (6): 653-660. 10.1007/s10024-004-6065-7CrossRefPubMed
30.
Anders JO, Aurich M, Lang T, Wagner A: Solitary fibrous tumor in the thigh: review of the literature. J Cancer Res Clin Oncol. 2006, 132 (2): 69-75. 10.1007/s00432-005-0055-7CrossRefPubMed
31.
Daigeler A, Lehnhardt M, Langer S, Steinstraesser L, Steinau HU, Mentzel T, Kuhnen C: Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues. BMC Surg. 2006, 6 (6): 10-PubMedCentralCrossRefPubMed
32.
Martorell M, Pérez-Vallés A, Gozalbo F, Garcia-Garcia JA, Gutierrez J, Gaona J: Solitary fibrous tumor of the thigh with epithelioid features: a case report. Diagn Pathol. 2007, 2: 19- 10.1186/1746-1596-2-19PubMedCentralCrossRefPubMed
33.
Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ: Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol. 2009, 35 (9): 994-998. 10.1016/j.ejso.2009.02.015CrossRefPubMed
34.
Tateishi U, Nishihara H, Morikawa T, Miyasaka K: Solitary fibrous tumor of the pleura: MR appearance and enhancement pattern. J Comput Assist Tomogr. 2002, 26 (2): 174-179. 10.1097/00004728-200203000-00002CrossRefPubMed
35.
Chong S, Kim TS, Cho EY, Kim J, Kim H: Benign localized fibrous tumour of the pleura: CT features with histopathological correlations. Clin Radiol. 2006, 61: 875-882. 10.1016/j.crad.2006.06.008CrossRefPubMed
36.
Rosado-de-Christenson ML, Abbott GF, McAdams HP, Franks TJ, Galvin JR: From the archives of the AFIP: localized fibrous tumor of the pleura. Radiographics. 2003, 23 (3): 759-783. 10.1148/rg.233025165CrossRefPubMed
37.
Ferretti GR, Chiles C, Cox JE, Choplin RH, Coulomb M: Localized benign fibrous tumors of the pleura: MR appearance. J Comput Assist Tomogr. 1997, 21: 115-120. 10.1097/00004728-199701000-00023CrossRefPubMed
38.
Kransdorf MJ, Jelineck JS, Moser RP, Utz JA, Hudson TM, Neal J: Magnetic resonance appearance of fibromatosis. A report of 14 cases and review of the literature. Skeletal Radiol. 1990, 19: 495-499.CrossRefPubMed
Metadata
Title
Solitary fibrous tumors of the soft tissues: imaging features with histopathologic correlations
Authors
Zafaria G Papathanassiou
Marco Alberghini
Piero Picci
Eric Staals
Marco Gambarotti
Francesco Giuseppe Garaci
Daniel Vanel
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Clinical Sarcoma Research / Issue 1/2013
Electronic ISSN: 2045-3329
DOI
https://doi.org/10.1186/2045-3329-3-1

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