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Experimental & Translational Stroke Medicine

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Open Access 01-12-2014 | Short report

Glatiramer acetate does not protect from acute ischemic stroke in mice

Authors: Peter Kraft, Kerstin Göbel, Sven G Meuth, Christoph Kleinschnitz

Published in: Experimental & Translational Stroke Medicine | Issue 1/2014

Abstract

Background

The role of the immune system in the pathophysiology of acute ischemic stroke is increasingly recognized. However, targeted treatment strategies to modulate immunological pathways in stroke are still lacking. Glatiramer acetate is a multifaceted immunomodulator approved for the treatment of relapsing-remitting multiple sclerosis. Experimental studies suggest that glatiramer acetate might also work in other neuroinflammatory or neurodegenerative diseases apart from multiple sclerosis.

Findings

We evaluated the efficacy of glatiramer acetate in a mouse model of brain ischemia/reperfusion injury. 60 min of transient middle cerebral artery occlusion was induced in male C57Bl/6 mice. Pretreatment with glatiramer acetate (3.5 mg/kg bodyweight) 30 min before the induction of stroke did not reduce lesion volumes or improve functional outcome on day 1.

Conclusions

Glatiramer acetate failed to protect from acute ischemic stroke in our hands. Further studies are needed to assess the true therapeutic potential of glatiramer acetate and related immunomodulators in brain ischemia.

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Title: Glatiramer acetate does not protect from acute ischemic stroke in mice
Authors: Peter Kraft
Kerstin Göbel
Sven G Meuth
Christoph Kleinschnitz
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Experimental & Translational Stroke Medicine / Issue 1/2014
Electronic ISSN: 2040-7378
DOI: https://doi.org/10.1186/2040-7378-6-4

ACC 2024 Congress

Springer Medicine

Glatiramer acetate does not protect from acute ischemic stroke in mice

Abstract

Background

Findings

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Findings

Conclusions

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